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Lipophilicity Modulations by Fluorination Correlate with Membrane Partitioning.
Angew Chem Int Ed Engl. 2023 May 15;62(21):e202301077. doi: 10.1002/anie.202301077. Epub 2023 Apr 17.
Angew Chem Int Ed Engl. 2023.
PMID: 36932824
Free PMC article.
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups.
Jeffries B, Wang Z, Troup RI, Goupille A, Le Questel JY, Fallan C, Scott JS, Chiarparin E, Graton J, Linclau B.
Jeffries B, et al. Among authors: troup ri.
Beilstein J Org Chem. 2020 Sep 2;16:2141-2150. doi: 10.3762/bjoc.16.182. eCollection 2020.
Beilstein J Org Chem. 2020.
PMID: 32952731
Free PMC article.
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Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs.
Troup RI, Jeffries B, Saudain RE, Georgiou E, Fish J, Scott JS, Chiarparin E, Fallan C, Linclau B.
Troup RI, et al.
J Org Chem. 2021 Jan 15;86(2):1882-1900. doi: 10.1021/acs.joc.0c02810. Epub 2021 Jan 5.
J Org Chem. 2021.
PMID: 33400526
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Current strategies for the design of PROTAC linkers: a critical review.
Troup RI, Fallan C, Baud MGJ.
Troup RI, et al.
Explor Target Antitumor Ther. 2020;1(5):273-312. doi: 10.37349/etat.2020.00018. Epub 2020 Oct 30.
Explor Target Antitumor Ther. 2020.
PMID: 36046485
Free PMC article.
Review.
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Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
McCoull W, Boyd S, Brown MR, Coen M, Collingwood O, Davies NL, Doherty A, Fairley G, Goldberg K, Hardaker E, He G, Hennessy EJ, Hopcroft P, Hodgson G, Jackson A, Jiang X, Karmokar A, Lainé AL, Lindsay N, Mao Y, Markandu R, McMurray L, McLean N, Mooney L, Musgrove H, Nissink JWM, Pflug A, Reddy VP, Rawlins PB, Rivers E, Schimpl M, Smith GF, Tentarelli S, Travers J, Troup RI, Walton J, Wang C, Wilkinson S, Williamson B, Winter-Holt J, Yang D, Zheng Y, Zhu Q, Smith PD.
McCoull W, et al. Among authors: troup ri.
J Med Chem. 2021 Sep 23;64(18):13524-13539. doi: 10.1021/acs.jmedchem.1c00920. Epub 2021 Sep 3.
J Med Chem. 2021.
PMID: 34478292
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