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A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.
Wetzel S, Wilk W, Chammaa S, Sperl B, Roth AG, Yektaoglu A, Renner S, Berg T, Arenz C, Giannis A, Oprea TI, Rauh D, Kaiser M, Waldmann H. Wetzel S, et al. Among authors: waldmann h. Angew Chem Int Ed Engl. 2010 May 10;49(21):3666-70. doi: 10.1002/anie.200906555. Angew Chem Int Ed Engl. 2010. PMID: 20394088 No abstract available.
Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H. Dekker FJ, et al. Among authors: waldmann h. Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25. Nat Chem Biol. 2010. PMID: 20418879
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.
Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, Triola G, Brockmeyer A, Janning P, Böttcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H. Rusch M, et al. Among authors: waldmann h. Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9838-42. doi: 10.1002/anie.201102967. Epub 2011 Sep 9. Angew Chem Int Ed Engl. 2011. PMID: 21905186
Biology-oriented synthesis.
Wetzel S, Bon RS, Kumar K, Waldmann H. Wetzel S, et al. Among authors: waldmann h. Angew Chem Int Ed Engl. 2011 Nov 11;50(46):10800-26. doi: 10.1002/anie.201007004. Epub 2011 Oct 28. Angew Chem Int Ed Engl. 2011. PMID: 22038946 Review.
Natural product-inspired cascade synthesis yields modulators of centrosome integrity.
Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, Kumar K, Waldmann H. Dückert H, et al. Among authors: waldmann h. Nat Chem Biol. 2011 Dec 25;8(2):179-84. doi: 10.1038/nchembio.758. Nat Chem Biol. 2011. PMID: 22198731
1,022 results