Harki DA - Search Results

1

APOBEC3A Catalytic Inactivity Mutation Induces Tertiary Structure Destabilization.

Jones KFM, Shehata M, Carpenter MA, Amaro RE, Harki DA. Jones KFM, et al. Among authors: harki da. ACS Med Chem Lett. 2023 Feb 14;14(3):338-343. doi: 10.1021/acsmedchemlett.2c00517. eCollection 2023 Mar 9. ACS Med Chem Lett. 2023. PMID: 36923917 Free PMC article.

2

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. Li M, et al. Among authors: harki da. ACS Chem Biol. 2012 Mar 16;7(3):506-17. doi: 10.1021/cb200440y. Epub 2012 Jan 17. ACS Chem Biol. 2012. PMID: 22181350 Free PMC article.

3

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

Olson ME, Abate-Pella D, Perkins AL, Li M, Carpenter MA, Rathore A, Harris RS, Harki DA. Olson ME, et al. Among authors: harki da. J Med Chem. 2015 Sep 24;58(18):7419-30. doi: 10.1021/acs.jmedchem.5b00930. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26358009 Free PMC article.

4

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.

Richards C, Albin JS, Demir Ö, Shaban NM, Luengas EM, Land AM, Anderson BD, Holten JR, Anderson JS, Harki DA, Amaro RE, Harris RS. Richards C, et al. Among authors: harki da. Cell Rep. 2015 Dec 1;13(9):1781-8. doi: 10.1016/j.celrep.2015.10.067. Epub 2015 Nov 25. Cell Rep. 2015. PMID: 26628363 Free PMC article.

5

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.

Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H. Shi K, et al. Among authors: harki da. Nat Struct Mol Biol. 2017 Feb;24(2):131-139. doi: 10.1038/nsmb.3344. Epub 2016 Dec 19. Nat Struct Mol Biol. 2017. PMID: 27991903 Free PMC article.

6

Determinants of Oligonucleotide Selectivity of APOBEC3B.

Wagner JR, Demir Ö, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE. Wagner JR, et al. Among authors: harki da. J Chem Inf Model. 2019 May 28;59(5):2264-2273. doi: 10.1021/acs.jcim.8b00427. Epub 2018 Sep 10. J Chem Inf Model. 2019. PMID: 30130104 Free PMC article.

7

Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2'-Deoxyzebularine Embedded in Single-Stranded DNA.

Kvach MV, Barzak FM, Harjes S, Schares HAM, Kurup HM, Jones KF, Sutton L, Donahue J, D'Aquila RT, Jameson GB, Harki DA, Krause KL, Harjes E, Filichev VV. Kvach MV, et al. Among authors: harki da. Chembiochem. 2020 Apr 1;21(7):1028-1035. doi: 10.1002/cbic.201900505. Epub 2019 Dec 19. Chembiochem. 2020. PMID: 31633265 Free PMC article.

8

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B.

Shi K, Demir Ö, Carpenter MA, Banerjee S, Harki DA, Amaro RE, Harris RS, Aihara H. Shi K, et al. Among authors: harki da. FASEB Bioadv. 2019 Dec 24;2(1):49-58. doi: 10.1096/fba.2019-00068. eCollection 2020 Jan. FASEB Bioadv. 2019. PMID: 32123856 Free PMC article.

9

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

Jackson PA, Schares HAM, Jones KFM, Widen JC, Dempe DP, Grillet F, Cuellar ME, Walters MA, Harki DA, Brummond KM. Jackson PA, et al. Among authors: harki da. J Med Chem. 2020 Dec 10;63(23):14951-14978. doi: 10.1021/acs.jmedchem.0c01464. Epub 2020 Nov 17. J Med Chem. 2020. PMID: 33201697 Free PMC article.

10

Function-Oriented and Modular (+/-)-cis-Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF-κB Inhibitors.

Emmetiere F, Ratnayake R, Schares HAM, Jones KFM, Bevan-Smith E, Luesch H, Harki DA, Grenning AJ. Emmetiere F, et al. Among authors: harki da. Chemistry. 2021 Mar 22;27(17):5564-5571. doi: 10.1002/chem.202100038. Epub 2021 Feb 26. Chemistry. 2021. PMID: 33502811 Free PMC article.

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