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Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells.
Saha N, Baek DS, Mendoza RP, Robev D, Xu Y, Goldgur Y, De La Cruz MJ, de Stanchina E, Janes PW, Xu K, Dimitrov DS, Nikolov DB. Saha N, et al. Among authors: janes pw. Biomed Pharmacother. 2023 May;161:114494. doi: 10.1016/j.biopha.2023.114494. Epub 2023 Mar 12. Biomed Pharmacother. 2023. PMID: 36917886 Free PMC article.
Architecture of Eph receptor clusters.
Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Himanen JP, et al. Among authors: janes pw. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10860-5. doi: 10.1073/pnas.1004148107. Epub 2010 May 26. Proc Natl Acad Sci U S A. 2010. PMID: 20505120 Free PMC article.
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, Rafii S, Ernst M, Scott AM, Nikolov DB, Lackmann M, Janes PW. Atapattu L, et al. Among authors: janes pw. J Exp Med. 2016 Aug 22;213(9):1741-57. doi: 10.1084/jem.20151095. Epub 2016 Aug 8. J Exp Med. 2016. PMID: 27503072 Free PMC article.
Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Seegar TCM, et al. Among authors: janes pw. Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7. Cell. 2017. PMID: 29224781 Free PMC article.
Antibody Targeting of Eph Receptors in Cancer.
Janes PW, Vail ME, Gan HK, Scott AM. Janes PW, et al. Pharmaceuticals (Basel). 2020 May 8;13(5):88. doi: 10.3390/ph13050088. Pharmaceuticals (Basel). 2020. PMID: 32397088 Free PMC article. Review.
Eph Receptors in Cancer.
Arora S, Scott AM, Janes PW. Arora S, et al. Among authors: janes pw. Biomedicines. 2023 Jan 23;11(2):315. doi: 10.3390/biomedicines11020315. Biomedicines. 2023. PMID: 36830852 Free PMC article. Review.
40 results