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APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.
Hernández-Jiménez M, Abad-Santos F, Cotgreave I, Gallego J, Jilma B, Flores A, Jovin TG, Vivancos J, Molina CA, Montaner J, Casariego J, Dalsgaard M, Hernández-Pérez M, Liebeskind DS, Cobo E, Ribo M. Hernández-Jiménez M, et al. Front Neurol. 2023 Feb 24;14:1127585. doi: 10.3389/fneur.2023.1127585. eCollection 2023. Front Neurol. 2023. PMID: 36908619 Free PMC article.
Defining a Target Population to Effectively Test a Neuroprotective Drug.
Olivé-Gadea M, Requena M, Campos D, Garcia-Tornel A, Deck M, Muchada M, Boned S, Rodríguez N, Juega J, Rodríguez-Luna D, Pagola J, Rubiera M, Hernández-Jiménez M, Molina CA, Ribo M. Olivé-Gadea M, et al. Stroke. 2021 Jan;52(2):505-510. doi: 10.1161/STROKEAHA.120.032025. Epub 2021 Jan 11. Stroke. 2021. PMID: 33423513
First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers.
Hernández-Jiménez M, Martín-Vílchez S, Ochoa D, Mejía-Abril G, Román M, Camargo-Mamani P, Luquero-Bueno S, Jilma B, Moro MA, Fernández G, Piñeiro D, Ribó M, González VM, Lizasoain I, Abad-Santos F. Hernández-Jiménez M, et al. Mol Ther Nucleic Acids. 2022 Mar 9;28:124-135. doi: 10.1016/j.omtn.2022.03.005. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35402075 Free PMC article.
Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial.
Hernández-Jiménez M, Abad-Santos F, Cotgreave I, Gallego J, Jilma B, Flores A, Jovin TG, Vivancos J, Hernández-Pérez M, Molina CA, Montaner J, Casariego J, Dalsgaard M, Liebeskind DS, Cobo E, Castellanos M, Portela PC, Masjuán J, Moniche F, Tembl JI, Terceño Izaga M, Arenillas JF, Callejas P, Olivot JM, Calviere L, Henon H, Mazighi M, Piñeiro D, Pugliese M, González VM, Moro MA, Garcia-Tornel A, Lizasoain I, Ribo M. Hernández-Jiménez M, et al. JAMA Neurol. 2023 Aug 1;80(8):779-788. doi: 10.1001/jamaneurol.2023.1660. JAMA Neurol. 2023. PMID: 37338893 Clinical Trial.
Enhancing Enrollment in Acute Stroke Trials: Current State and Consensus Recommendations.
Broderick JP, Silva GS, Selim M, Kasner SE, Aziz Y, Sutherland J, Jauch EC, Adeoye OM, Hill MD, Mistry EA, Lyden PD, Mocco J, Smith EM, Hernandez-Jimenez M, Deljkich E, Kamel H; STAIR XII Participants. Broderick JP, et al. Among authors: hernandez jimenez m. Stroke. 2023 Oct;54(10):2698-2707. doi: 10.1161/STROKEAHA.123.044149. Epub 2023 Sep 11. Stroke. 2023. PMID: 37694403 Free article. Review.
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis.
Fernández-Gómez B, Marchena MA, Piñeiro D, Gómez-Martín P, Sánchez E, Laó Y, Valencia G, Nocera S, Benítez-Fernández R, Castaño-León AM, Lagares A, Hernández-Jiménez M, de Castro F. Fernández-Gómez B, et al. Among authors: hernandez jimenez m. Br J Pharmacol. 2024 May 14. doi: 10.1111/bph.16399. Online ahead of print. Br J Pharmacol. 2024. PMID: 38742374
Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice.
Fraga E, Medina V, Cuartero MI, García-Culebras A, Bravo-Ferrer I, Hernández-Jiménez M, Garcia-Segura JM, Hurtado O, Pradillo JM, Lizasoain I, Moro MÁ. Fraga E, et al. Among authors: hernandez jimenez m. Front Cell Neurosci. 2023 Aug 11;17:1219847. doi: 10.3389/fncel.2023.1219847. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37636586 Free PMC article.
Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance.
Peña-Martínez C, Durán-Laforet V, García-Culebras A, Ostos F, Hernández-Jiménez M, Bravo-Ferrer I, Pérez-Ruiz A, Ballenilla F, Díaz-Guzmán J, Pradillo JM, Lizasoain I, Moro MA. Peña-Martínez C, et al. Stroke. 2019 Nov;50(11):3228-3237. doi: 10.1161/STROKEAHA.119.026848. Epub 2019 Sep 17. Stroke. 2019. PMID: 31526124
TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models.
Fernández G, Moraga A, Cuartero MI, García-Culebras A, Peña-Martínez C, Pradillo JM, Hernández-Jiménez M, Sacristán S, Ayuso MI, Gonzalo-Gobernado R, Fernández-López D, Martín ME, Moro MA, González VM, Lizasoain I. Fernández G, et al. Mol Ther. 2018 Aug 1;26(8):2047-2059. doi: 10.1016/j.ymthe.2018.05.019. Epub 2018 Jun 15. Mol Ther. 2018. PMID: 29910175 Free PMC article.
53 results