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A phase 1b study of the allosteric extracellular FGFR2 inhibitor alofanib in patients with pretreated advanced gastric cancer.
Tsimafeyeu I, Statsenko G, Vladimirova L, Besova N, Artamonova E, Raskin G, Rykov I, Mochalova A, Utyashev I, Gorbacheva S, Kazey V, Gavrilova E, Dragun N, Moiseyenko V, Tjulandin S. Tsimafeyeu I, et al. Invest New Drugs. 2023 Apr;41(2):324-332. doi: 10.1007/s10637-023-01340-z. Epub 2023 Mar 13. Invest New Drugs. 2023. PMID: 36907947 Clinical Trial.
Current Role of Radiotherapy for Renal-Cell Carcinoma: Review.
Dengina N, Tsimafeyeu I, Mitin T. Dengina N, et al. Among authors: tsimafeyeu i. Clin Genitourin Cancer. 2017 Apr;15(2):183-187. doi: 10.1016/j.clgc.2016.09.004. Epub 2016 Sep 19. Clin Genitourin Cancer. 2017. PMID: 27789182 Review.
Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models.
Tsimafeyeu I, Ludes-Meyers J, Stepanova E, Daeyaert F, Khochenkov D, Joose JB, Solomko E, Van Akene K, Peretolchina N, Yin W, Ryabaya O, Byakhov M, Tjulandin S. Tsimafeyeu I, et al. Eur J Cancer. 2016 Jul;61:20-8. doi: 10.1016/j.ejca.2016.03.068. Epub 2016 Apr 29. Eur J Cancer. 2016. PMID: 27136102
Alofanib, an allosteric FGFR2 inhibitor, has potent effects on ovarian cancer growth in preclinical studies.
Tyulyandina A, Harrison D, Yin W, Stepanova E, Kochenkov D, Solomko E, Peretolchina N, Daeyaert F, Joos JB, Van Aken K, Byakhov M, Gavrilova E, Tjulandin S, Tsimafeyeu I. Tyulyandina A, et al. Among authors: tsimafeyeu i. Invest New Drugs. 2017 Apr;35(2):127-133. doi: 10.1007/s10637-016-0404-1. Epub 2016 Nov 3. Invest New Drugs. 2017. PMID: 27812884
50 results