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Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin.
Williams JN, Irwin M, Li Y, Kambrath AV, Mattingly BT, Patel S, Kittaka M, Collins RN, Clough NA, Doud EH, Mosley AL, Bellido T, Bruzzaniti A, Plotkin LI, Trinidad JC, Thompson WR, Bonewald LF, Sankar U. Williams JN, et al. Among authors: thompson wr. Int J Mol Sci. 2023 Mar 1;24(5):4718. doi: 10.3390/ijms24054718. Int J Mol Sci. 2023. PMID: 36902150 Free PMC article.
Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification.
Williams JN, Kambrath AV, Patel RB, Kang KS, Mével E, Li Y, Cheng YH, Pucylowski AJ, Hassert MA, Voor MJ, Kacena MA, Thompson WR, Warden SJ, Burr DB, Allen MR, Robling AG, Sankar U. Williams JN, et al. Among authors: thompson wr. J Bone Miner Res. 2018 May;33(5):930-944. doi: 10.1002/jbmr.3379. Epub 2018 Feb 5. J Bone Miner Res. 2018. PMID: 29314250 Free PMC article.
Systemic inhibition or global deletion of CaMKK2 protects against post-traumatic osteoarthritis.
Mével E, Shutter JA, Ding X, Mattingly BT, Williams JN, Li Y, Huls A, Kambrath AV, Trippel SB, Wagner D, Allen MR, O'Keefe R, Thompson WR, Burr DB, Sankar U. Mével E, et al. Among authors: thompson wr. Osteoarthritis Cartilage. 2022 Jan;30(1):124-136. doi: 10.1016/j.joca.2021.09.001. Epub 2021 Sep 17. Osteoarthritis Cartilage. 2022. PMID: 34506942 Free PMC article.
Generation of two multipotent mesenchymal progenitor cell lines capable of osteogenic, mature osteocyte, adipogenic, and chondrogenic differentiation.
Prideaux M, Wright CS, Noonan ML, Yi X, Clinkenbeard EL, Mevel E, Wheeler JA, Byers S, Wijenayaka AR, Gronthos S, Sankar U, White KE, Atkins GJ, Thompson WR. Prideaux M, et al. Among authors: thompson wr. Sci Rep. 2021 Nov 19;11(1):22593. doi: 10.1038/s41598-021-02060-1. Sci Rep. 2021. PMID: 34799645 Free PMC article.
Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation.
Reyes Fernandez PC, Wright CS, Masterson AN, Yi X, Tellman TV, Bonteanu A, Rust K, Noonan ML, White KE, Lewis KJ, Sankar U, Hum JM, Bix G, Wu D, Robling AG, Sardar R, Farach-Carson MC, Thompson WR. Reyes Fernandez PC, et al. Among authors: thompson wr. Biomolecules. 2022 Dec 12;12(12):1857. doi: 10.3390/biom12121857. Biomolecules. 2022. PMID: 36551284 Free PMC article.
Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease.
Agoro R, Nookaew I, Noonan ML, Marambio YG, Liu S, Chang W, Gao H, Hibbard LM, Metzger CE, Horan D, Thompson WR, Xuei X, Liu Y, Zhang C, Robling AG, Bonewald LF, Wan J, White KE. Agoro R, et al. Among authors: thompson wr. Front Endocrinol (Lausanne). 2023 Jan 26;14:1063083. doi: 10.3389/fendo.2023.1063083. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36777346 Free PMC article.
Deletion of the auxiliary α2δ1 voltage sensitive calcium channel subunit in osteocytes and late-stage osteoblasts impairs femur strength and load-induced bone formation in male mice.
Wright CS, Lewis KJ, Semon K, Yi X, Reyes Fernandez PC, Rust K, Prideaux M, Schneider A, Pederson M, Deosthale P, Plotkin LI, Hum JM, Sankar U, Farach-Carson MC, Robling AG, Thompson WR. Wright CS, et al. Among authors: thompson wr. J Bone Miner Res. 2024 Apr 19;39(3):298-314. doi: 10.1093/jbmr/zjae010. J Bone Miner Res. 2024. PMID: 38477790
Loss of the auxiliary α2δ1 voltage-sensitive calcium channel subunit impairs bone formation and anabolic responses to mechanical loading.
Kelly MM, Sharma K, Wright CS, Yi X, Reyes Fernandez PC, Gegg AT, Gorrell TA, Noonan ML, Baghdady A, Sieger JA, Dolphin AC, Warden SJ, Deosthale P, Plotkin LI, Sankar U, Hum JM, Robling AG, Farach-Carson MC, Thompson WR. Kelly MM, et al. Among authors: thompson wr. JBMR Plus. 2024 Jan 10;8(2):ziad008. doi: 10.1093/jbmrpl/ziad008. eCollection 2024 Feb. JBMR Plus. 2024. PMID: 38505532 Free PMC article.
320 results