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Focused ultrasound on the substantia nigra enables safe neurotensin-polyplex nanoparticle-mediated gene delivery to dopaminergic neurons intranasally and by blood circulation.
Mascotte-Cruz JU, Vera A, Leija L, Lopez-Salas FE, Gradzielski M, Koetz J, Gatica-García B, Rodríguez-Oviedo CP, Valenzuela-Arzeta IE, Escobedo L, Reyes-Corona D, Gutierrez-Castillo ME, Maldonado-Berny M, Espadas-Alvarez AJ, Orozco-Barrios CE, Martinez-Fong D. Mascotte-Cruz JU, et al. Among authors: gatica garcia b. Discov Nano. 2024 Apr 2;19(1):60. doi: 10.1186/s11671-024-04005-9. Discov Nano. 2024. PMID: 38564106 Free PMC article.
Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy.
Gatica-Garcia B, Bannon MJ, Martínez-Dávila IA, Soto-Rojas LO, Reyes-Corona D, Escobedo L, Maldonado-Berny M, Gutierrez-Castillo ME, Espadas-Alvarez AJ, Fernandez-Parrilla MA, Mascotte-Cruz JU, Rodríguez-Oviedo CP, Valenzuela-Arzeta IE, Luna-Herrera C, Lopez-Salas FE, Santoyo-Salazar J, Martinez-Fong D. Gatica-Garcia B, et al. Neural Regen Res. 2024 Sep 1;19(9):2057-2067. doi: 10.4103/1673-5374.391190. Epub 2023 Dec 21. Neural Regen Res. 2024. PMID: 38227536 Free PMC article.
LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat.
Valenzuela-Arzeta IE, Soto-Rojas LO, Flores-Martinez YM, Delgado-Minjares KM, Gatica-Garcia B, Mascotte-Cruz JU, Nava P, Aparicio-Trejo OE, Reyes-Corona D, Martínez-Dávila IA, Gutierrez-Castillo ME, Espadas-Alvarez AJ, Orozco-Barrios CE, Martinez-Fong D. Valenzuela-Arzeta IE, et al. Among authors: gatica garcia b. Int J Mol Sci. 2023 Feb 27;24(5):4628. doi: 10.3390/ijms24054628. Int J Mol Sci. 2023. PMID: 36902058 Free PMC article.
Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra.
Luna-Herrera C, Martínez-Dávila IA, Soto-Rojas LO, Flores-Martinez YM, Fernandez-Parrilla MA, Ayala-Davila J, León-Chavez BA, Soto-Rodriguez G, Blanco-Alvarez VM, Lopez-Salas FE, Gutierrez-Castillo ME, Gatica-Garcia B, Padilla-Viveros A, Bañuelos C, Reyes-Corona D, Espadas-Alvarez AJ, Garcés-Ramírez L, Hidalgo-Alegria O, De La Cruz-López F, Martinez-Fong D. Luna-Herrera C, et al. Among authors: gatica garcia b. J Immunol Res. 2020 Nov 16;2020:5907591. doi: 10.1155/2020/5907591. eCollection 2020. J Immunol Res. 2020. PMID: 33282962 Free PMC article.
Synthetic Monopartite Peptide That Enables the Nuclear Import of Genes Delivered by the Neurotensin-Polyplex Vector.
Lopez-Salas FE, Nadella R, Maldonado-Berny M, Escobedo-Sanchez ML, Fiorentino-Pérez R, Gatica-García B, Fernandez-Parrilla MA, Mario Gil M, Reyes-Corona D, García U, Orozco-Barrios CE, Gutierrez-Castillo ME, Martinez-Fong D. Lopez-Salas FE, et al. Among authors: gatica garcia b. Mol Pharm. 2020 Dec 7;17(12):4572-4588. doi: 10.1021/acs.molpharmaceut.0c00755. Epub 2020 Oct 30. Mol Pharm. 2020. PMID: 33125243
Unilateral intranigral administration of β-sitosterol β-D-glucoside triggers pathological α-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.
Soto-Rojas LO, Martínez-Dávila IA, Luna-Herrera C, Gutierrez-Castillo ME, Lopez-Salas FE, Gatica-Garcia B, Soto-Rodriguez G, Bringas Tobon ME, Flores G, Padilla-Viveros A, Bañuelos C, Blanco-Alvarez VM, Dávila-Ayala J, Reyes-Corona D, Garcés-Ramírez L, Hidalgo-Alegria O, De La Cruz-López F, Martinez-Fong D. Soto-Rojas LO, et al. Among authors: gatica garcia b. Acta Neuropathol Commun. 2020 Apr 22;8(1):56. doi: 10.1186/s40478-020-00933-6. Acta Neuropathol Commun. 2020. PMID: 32321590 Free PMC article.
A sequential methodology for integral evaluation of motor and non-motor behaviors in parkinsonian rodents.
Soto-Rojas LO, Bañuelos C, Garces-Ramirez L, Luna-Herrera C, Flores-Martínez YM, Soto-Rodríguez G, Gatica-García B, López-Salas FE, Ayala-Dávila J, Gutiérrez-Castillo ME, Padilla-Viveros A, de la Cruz-López F, Martínez-Davila IA, Martinez-Fong D. Soto-Rojas LO, et al. Among authors: gatica garcia b. MethodsX. 2020 Feb 20;7:100821. doi: 10.1016/j.mex.2020.100821. eCollection 2020. MethodsX. 2020. PMID: 32195138 Free PMC article.
A single intranigral administration of β-sitosterol β-d-glucoside elicits bilateral sensorimotor and non-motor alterations in the rat.
Soto-Rojas LO, Garces-Ramirez L, Luna-Herrera C, Flores-Martinez YM, Soto-Rodriguez G, Gatica-Garcia B, Lopez-Salas FE, Ayala-Davila J, Gutierrez-Castillo ME, Padilla-Viveros A, Bañuelos C, de la Cruz-Lopez F, Martinez-Davila IA, Martinez-Fong D. Soto-Rojas LO, et al. Among authors: gatica garcia b. Behav Brain Res. 2020 Jan 27;378:112279. doi: 10.1016/j.bbr.2019.112279. Epub 2019 Oct 10. Behav Brain Res. 2020. PMID: 31606429