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Initiation and modulation of Tau protein phase separation by the drug suramin.
Prince PR, Hochmair J, Brognaro H, Gevorgyan S, Franck M, Schubert R, Lorenzen K, Yazici S, Mandelkow E, Wegmann S, Betzel C. Prince PR, et al. Among authors: wegmann s. Sci Rep. 2023 Mar 9;13(1):3963. doi: 10.1038/s41598-023-29846-9. Sci Rep. 2023. PMID: 36894559 Free PMC article.
Oligomer formation of tau protein hyperphosphorylated in cells.
Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, Redecke L, Mandelkow EM, Müller DJ, Mandelkow E. Tepper K, et al. Among authors: wegmann s. J Biol Chem. 2014 Dec 5;289(49):34389-407. doi: 10.1074/jbc.M114.611368. Epub 2014 Oct 22. J Biol Chem. 2014. PMID: 25339173 Free PMC article.
Atypical, non-standard functions of the microtubule associated Tau protein.
Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, Buee L. Sotiropoulos I, et al. Among authors: wegmann s. Acta Neuropathol Commun. 2017 Nov 29;5(1):91. doi: 10.1186/s40478-017-0489-6. Acta Neuropathol Commun. 2017. PMID: 29187252 Free PMC article. Review.
Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Wegmann S, et al. EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22. EMBO J. 2018. PMID: 29472250 Free PMC article.
85 results