Yu T - Search Results

1

Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy.

Zeng R, Yang XM, Li HW, Li X, Guan Y, Yu T, Yan P, Yuan W, Niu SL, Gu J, Chen YC, Ouyang Q. Zeng R, et al. Among authors: yu t. J Med Chem. 2023 Mar 23;66(6):4086-4105. doi: 10.1021/acs.jmedchem.2c02061. Epub 2023 Mar 9. J Med Chem. 2023. PMID: 36892076

2

Correction to "Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy".

Zeng R, Yang XM, Li HW, Li X, Guan Y, Yu T, Yan P, Yuan W, Niu SL, Gu J, Chen YC, Ouyang Q. Zeng R, et al. Among authors: yu t. J Med Chem. 2023 Nov 9;66(21):15054. doi: 10.1021/acs.jmedchem.3c01899. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37862580 No abstract available.

3

Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library.

Yu T, Zeng R, Guan Y, Pan B, Li HW, Gu J, Zheng PF, Qian Y, Ouyang Q. Yu T, et al. RSC Med Chem. 2024 Mar 27;15(5):1675-1685. doi: 10.1039/d4md00136b. eCollection 2024 May 22. RSC Med Chem. 2024. PMID: 38784466

4

Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.

Yu T, Tagat JR, Kerekes AD, Doll RJ, Zhang Y, Xiao Y, Esposite S, Belanger DB, Curran PJ, Mandal AK, Siddiqui MA, Shih NY, Basso AD, Liu M, Gray K, Tevar S, Jones J, Lee S, Liang L, Ponery S, Smith EB, Hruza A, Voigt J, Ramanathan L, Prosise W, Hu M. Yu T, et al. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8. doi: 10.1021/ml100063w. eCollection 2010 Aug 12. ACS Med Chem Lett. 2010. PMID: 24900197 Free PMC article.

5

Discovery of 3-Quinazolin-4(3H)-on-3-yl-2,N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors.

Dong J, Huang J, Zhou J, Tan Y, Jin J, Tan X, Wang B, Yu T, Wu C, Chen S, Wang TL. Dong J, et al. Among authors: yu t. ACS Med Chem Lett. 2020 Jun 10;11(7):1463-1469. doi: 10.1021/acsmedchemlett.0c00239. eCollection 2020 Jul 9. ACS Med Chem Lett. 2020. PMID: 32676155 Free PMC article.

6

Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

Belanger DB, Williams MJ, Curran PJ, Mandal AK, Meng Z, Rainka MP, Yu T, Shih NY, Siddiqui MA, Liu M, Tevar S, Lee S, Liang L, Gray K, Yaremko B, Jones J, Smith EB, Prelusky DB, Basso AD. Belanger DB, et al. Among authors: yu t. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. doi: 10.1016/j.bmcl.2010.08.140. Epub 2010 Sep 18. Bioorg Med Chem Lett. 2010. PMID: 20855207

7

Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR.

Yu T, Li N, Wu C, Guan A, Li Y, Peng Z, He M, Li J, Gong Z, Huang L, Gao B, Hao D, Sun J, Pan Y, Shen L, Chan C, Lu X, Yuan H, Li Y, Li J, Chen S. Yu T, et al. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261. doi: 10.1021/acsmedchemlett.8b00002. eCollection 2018 Mar 8. ACS Med Chem Lett. 2018. PMID: 29541370 Free PMC article.

8

Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.

Yu T, Zhang Y, Kerekes AD, Tagat JR, Doll RJ, Xiao Y, Esposite S, Hruza A, Belanger DB, Voss M, Rainka MP, Basso A, Liu M, Liang L, Sui N, Prelusky D, Rindgen D, Zhang L. Yu T, et al. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403. doi: 10.1016/j.bmcl.2018.02.037. Epub 2018 Feb 23. Bioorg Med Chem Lett. 2018. PMID: 29545102

9

Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors.

Xu B, Sun Y, Guo Y, Cao Y, Yu T. Xu B, et al. Among authors: yu t. Bioorg Med Chem. 2009 Apr 1;17(7):2767-74. doi: 10.1016/j.bmc.2009.02.039. Epub 2009 Feb 25. Bioorg Med Chem. 2009. PMID: 19269831

10

Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG.

Shao S, Tsai MH, Lu J, Yu T, Jin J, Xiao D, Jiang H, Han M, Wang M, Wang J. Shao S, et al. Among authors: yu t. Bioorg Med Chem Lett. 2018 May 1;28(8):1363-1370. doi: 10.1016/j.bmcl.2018.03.005. Epub 2018 Mar 3. Bioorg Med Chem Lett. 2018. PMID: 29559276

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