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Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M. Murk K, et al. Among authors: rothkegel m. PLoS One. 2012;7(3):e34167. doi: 10.1371/journal.pone.0034167. Epub 2012 Mar 28. PLoS One. 2012. PMID: 22470532 Free PMC article.
Fine-tuning of neuronal architecture requires two profilin isoforms.
Michaelsen K, Murk K, Zagrebelsky M, Dreznjak A, Jockusch BM, Rothkegel M, Korte M. Michaelsen K, et al. Among authors: rothkegel m. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15780-5. doi: 10.1073/pnas.1004406107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798032 Free PMC article.
Tumor suppressor activity of profilin requires a functional actin binding site.
Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S, Jockusch BM. Wittenmayer N, et al. Among authors: rothkegel m. Mol Biol Cell. 2004 Apr;15(4):1600-8. doi: 10.1091/mbc.e03-12-0873. Epub 2004 Feb 6. Mol Biol Cell. 2004. PMID: 14767055 Free PMC article.
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