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Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation.
Mehta B, Goodman S, DiCarlo E, Jannat-Khah D, Gibbons JAB, Otero M, Donlin L, Pannellini T, Robinson WH, Sculco P, Figgie M, Rodriguez J, Kirschmann JM, Thompson J, Slater D, Frezza D, Xu Z, Wang F, Orange DE. Mehta B, et al. Among authors: donlin l. Arthritis Res Ther. 2023 Mar 2;25(1):31. doi: 10.1186/s13075-023-03008-8. Arthritis Res Ther. 2023. PMID: 36864474 Free PMC article.
iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.
Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE. Qing X, et al. Among authors: donlin l. J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5. J Clin Invest. 2018. PMID: 29369823 Free PMC article.
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.
Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Rao DA, et al. Among authors: donlin lt. Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810. Nature. 2017. PMID: 28150777 Free PMC article.
Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.
Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network; Bykerk VP, Goodman SM, Donlin LT. Orange DE, et al. Arthritis Rheumatol. 2018 May;70(5):690-701. doi: 10.1002/art.40428. Epub 2018 Apr 2. Arthritis Rheumatol. 2018. PMID: 29468833 Free PMC article.
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.
Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Mizoguchi F, et al. Among authors: donlin lt. Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y. Nat Commun. 2018. PMID: 29476097 Free PMC article.
Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue.
Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network; Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. Donlin LT, et al. Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y. Arthritis Res Ther. 2018. PMID: 29996944 Free PMC article.
Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission.
Orange DE, Agius P, DiCarlo EF, Mirza SZ, Pannellini T, Szymonifka J, Jiang CS, Figgie MP, Frank MO, Robinson WH, Donlin LT, Rozo C, Gravallese EM, Bykerk VP, Goodman SM. Orange DE, et al. Arthritis Rheumatol. 2019 Jul;71(7):1034-1041. doi: 10.1002/art.40878. Epub 2019 Jun 5. Arthritis Rheumatol. 2019. PMID: 30835943 Free PMC article.
55 results