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Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC.
Faux MC, Weinstock J, Gogos S, Prato E, Azimpour AI, O'Keefe R, Cathcart-King Y, Garnham AL, Ernst M, Preaudet A, Christie M, Putoczki TL, Buchert M, Burgess AW. Faux MC, et al. Among authors: garnham al. Cancer Res Commun. 2022 Feb 2;2(2):66-77. doi: 10.1158/2767-9764.CRC-21-0105. eCollection 2022 Feb. Cancer Res Commun. 2022. PMID: 36860494 Free PMC article.
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.
Wang Z, Burigotto M, Ghetti S, Vaillant F, Tan T, Capaldo BD, Palmieri M, Hirokawa Y, Tai L, Simpson DS, Chang C, Huang AS, Lieschke E, Diepstraten ST, Kaloni D, Riffkin C, Huang DCS, Li Wai Suen CSN, Garnham AL, Gibbs P, Visvader JE, Sieber OM, Herold MJ, Fava LL, Kelly GL, Strasser A. Wang Z, et al. Among authors: garnham al. Cancer Discov. 2024 Feb 8;14(2):362-379. doi: 10.1158/2159-8290.CD-23-0402. Cancer Discov. 2024. PMID: 37877779 Free PMC article.
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer.
Best SA, Gubser PM, Sethumadhavan S, Kersbergen A, Negrón Abril YL, Goldford J, Sellers K, Abeysekera W, Garnham AL, McDonald JA, Weeden CE, Anderson D, Pirman D, Roddy TP, Creek DJ, Kallies A, Kingsbury G, Sutherland KD. Best SA, et al. Among authors: garnham al. Cell Metab. 2022 Jun 7;34(6):874-887.e6. doi: 10.1016/j.cmet.2022.04.003. Epub 2022 May 2. Cell Metab. 2022. PMID: 35504291 Free article.
MLKL deficiency protects against low-grade, sterile inflammation in aged mice.
Tovey Crutchfield EC, Garnish SE, Day J, Anderton H, Chiou S, Hempel A, Hall C, Patel KM, Gangatirkar P, Martin KR, Li Wai Suen CSN, Garnham AL, Kueh AJ, Wicks IP, Silke J, Nachbur U, Samson AL, Murphy JM, Hildebrand JM. Tovey Crutchfield EC, et al. Among authors: garnham al. Cell Death Differ. 2023 Apr;30(4):1059-1071. doi: 10.1038/s41418-023-01121-4. Epub 2023 Feb 8. Cell Death Differ. 2023. PMID: 36755069 Free PMC article.
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A. Sidwell T, et al. Among authors: garnham al. Nat Commun. 2020 Jan 14;11(1):252. doi: 10.1038/s41467-019-14112-2. Nat Commun. 2020. PMID: 31937752 Free PMC article.
G-CSF drives autoinflammation in APLAID.
Mulazzani E, Kong K, Aróstegui JI, Ng AP, Ranathunga N, Abeysekera W, Garnham AL, Ng SL, Baker PJ, Jackson JT, Lich JD, Hibbs ML, Wicks IP, Louis C, Masters SL. Mulazzani E, et al. Among authors: garnham al. Nat Immunol. 2023 May;24(5):814-826. doi: 10.1038/s41590-023-01473-6. Epub 2023 Mar 30. Nat Immunol. 2023. PMID: 36997670 Free PMC article.
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Wang Z, Hu H, Heitink L, Rogers K, You Y, Tan T, Suen CLW, Garnham A, Chen H, Lieschke E, Diepstraten ST, Chang C, Chen T, Moujalled D, Sutherland K, Lessene G, Sieber OM, Visvader J, Kelly GL, Strasser A. Wang Z, et al. Cell Death Differ. 2023 Apr;30(4):1033-1046. doi: 10.1038/s41418-023-01122-3. Epub 2023 Feb 4. Cell Death Differ. 2023. PMID: 36739334 Free PMC article.
55 results