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Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin-responsive and proopiomelanocortin neurons in the arcuate nucleus.
Han W, Wang L, Ohbayashi K, Takeuchi M, O'Farrell L, Coskun T, Rakhat Y, Yabe D, Iwasaki Y, Seino Y, Yada T. Han W, et al. Among authors: o farrell l. Diabetes Obes Metab. 2023 Jun;25(6):1534-1546. doi: 10.1111/dom.15001. Epub 2023 Feb 28. Diabetes Obes Metab. 2023. PMID: 36852745
The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis.
Antonellis PJ, Droz BA, Cosgrove R, O'Farrell LS, Coskun T, Perfield JW 2nd, Bauer S, Wade M, Chouinard TE, Brozinick JT, Adams AC, Samms RJ. Antonellis PJ, et al. Mol Metab. 2019 Dec;30:131-139. doi: 10.1016/j.molmet.2019.09.006. Epub 2019 Sep 29. Mol Metab. 2019. PMID: 31767164 Free PMC article.
The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists.
Urva S, Coskun T, Loghin C, Cui X, Beebe E, O'Farrell L, Briere DA, Benson C, Nauck MA, Haupt A. Urva S, et al. Diabetes Obes Metab. 2020 Oct;22(10):1886-1891. doi: 10.1111/dom.14110. Epub 2020 Jul 13. Diabetes Obes Metab. 2020. PMID: 32519795 Free PMC article.
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.
Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, O'Farrell LS, Briere DA, Sloop KW, Thomas MK, Pirro V, Wainscott DB, Willard FS, Abernathy M, Morford L, Du Y, Benson C, Gimeno RE, Haupt A, Milicevic Z. Coskun T, et al. Among authors: o farrell ls. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9. doi: 10.1016/j.cmet.2022.07.013. Epub 2022 Aug 18. Cell Metab. 2022. PMID: 35985340 Free article.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice.
Furber EC, Hyatt K, Collins K, Yu X, Droz BA, Holland A, Friedrich JL, Wojnicki S, Konkol DL, O'Farrell LS, Baker HE, Coskun T, Scherer PE, Kusminski CM, Christe ME, Sloop KW, Samms RJ. Furber EC, et al. Among authors: o farrell ls. Diabetes. 2024 Feb 1;73(2):292-305. doi: 10.2337/db23-0172. Diabetes. 2024. PMID: 37934926 Free PMC article.
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation.
Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O'Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M. Li Y, et al. Cell. 2018 Nov 29;175(6):1561-1574.e12. doi: 10.1016/j.cell.2018.10.016. Epub 2018 Nov 15. Cell. 2018. PMID: 30449620 Free article.
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