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Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1.
Obasanmi G, Zeglinski MR, Hardie E, Wilhelm AC, Turner CT, Hiroyasu S, Boivin WA, Tian Y, Zhao H, To E, Cui JZ, Xi J, Yoo HS, Uppal M, Granville DJ, Matsubara JA. Obasanmi G, et al. Among authors: zhao h. Lab Invest. 2023 Jun;103(6):100123. doi: 10.1016/j.labinv.2023.100123. Epub 2023 Feb 26. Lab Invest. 2023. PMID: 36849037 Free article.
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ. Russo V, et al. Among authors: zhao h. Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0. Sci Rep. 2018. PMID: 29946113 Free PMC article.
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Hiroyasu S, Zeglinski MR, Zhao H, Pawluk MA, Turner CT, Kasprick A, Tateishi C, Nishie W, Burleigh A, Lennox PA, Van Laeken N, Carr NJ, Petersen F, Crawford RI, Shimizu H, Tsuruta D, Ludwig RJ, Granville DJ. Hiroyasu S, et al. Among authors: zhao h. Nat Commun. 2021 Jan 12;12(1):302. doi: 10.1038/s41467-020-20604-3. Nat Commun. 2021. PMID: 33436591 Free PMC article.
Granzyme B mediates impaired healing of pressure injuries in aged skin.
Turner CT, Bolsoni J, Zeglinski MR, Zhao H, Ponomarev T, Richardson K, Hiroyasu S, Schmid E, Papp A, Granville DJ. Turner CT, et al. Among authors: zhao h. NPJ Aging Mech Dis. 2021 Mar 5;7(1):6. doi: 10.1038/s41514-021-00059-6. NPJ Aging Mech Dis. 2021. PMID: 33674592 Free PMC article.
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