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Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake.
Mol Biochem Parasitol. 2024 Jun;258:111616. doi: 10.1016/j.molbiopara.2024.111616. Epub 2024 Feb 23.
Mol Biochem Parasitol. 2024.
PMID: 38401850
Free article.
Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis.
Ungogo MA, Aldfer MM, Natto MJ, Zhuang H, Chisholm R, Walsh K, McGee M, Ilbeigi K, Asseri JI, Burchmore RJS, Caljon G, Van Calenbergh S, De Koning HP.
Ungogo MA, et al. Among authors: aldfer mm.
Int J Mol Sci. 2023 Feb 5;24(4):3144. doi: 10.3390/ijms24043144.
Int J Mol Sci. 2023.
PMID: 36834557
Free PMC article.
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Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches.
Fiuza LFA, Batista DGJ, Girão RD, Hulpia F, Finamore-Araújo P, Aldfer MM, Elmahallawy EK, De Koning HP, Moreira O, Van Calenbergh S, Soeiro MNC.
Fiuza LFA, et al. Among authors: aldfer mm.
Molecules. 2022 Nov 21;27(22):8087. doi: 10.3390/molecules27228087.
Molecules. 2022.
PMID: 36432189
Free PMC article.
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The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues.
Aldfer MM, Alfayez IA, Elati HAA, Gayen N, Elmahallawy EK, Milena Murillo A, Marsiccobetre S, Van Calenbergh S, Silber AM, de Koning HP.
Aldfer MM, et al.
Molecules. 2022 Nov 19;27(22):0. doi: 10.3390/molecules27228045.
Molecules. 2022.
PMID: 36432150
Free PMC article.
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Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters.
Aldfer MM, AlSiari TA, Elati HAA, Natto MJ, Alfayez IA, Campagnaro GD, Sani B, Burchmore RJS, Diallinas G, De Koning HP.
Aldfer MM, et al.
Int J Mol Sci. 2022 Jul 23;23(15):8139. doi: 10.3390/ijms23158139.
Int J Mol Sci. 2022.
PMID: 35897714
Free PMC article.
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Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies.
Cisneros D, Cueto-Díaz EJ, Medina-Gil T, Chevillard R, Bernal-Fraile T, López-Sastre R, Aldfer MM, Ungogo MA, Elati HAA, Arai N, Otani M, Matsushiro S, Kojima C, Ebiloma GU, Shiba T, de Koning HP, Dardonville C.
Cisneros D, et al. Among authors: aldfer mm.
ACS Med Chem Lett. 2022 Jan 28;13(2):312-318. doi: 10.1021/acsmedchemlett.1c00717. eCollection 2022 Feb 10.
ACS Med Chem Lett. 2022.
PMID: 35178188
Free PMC article.
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Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites.
Robertson J, Ungogo MA, Aldfer MM, Lemgruber L, McWhinnie FS, Bode BE, Jones KL, Watson AJB, de Koning HP, Burley GA.
Robertson J, et al. Among authors: aldfer mm.
ChemMedChem. 2021 Nov 19;16(22):3396-3401. doi: 10.1002/cmdc.202100509. Epub 2021 Sep 2.
ChemMedChem. 2021.
PMID: 34357687
Free PMC article.
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