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Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes.
De Jesus DF, Zhang Z, Brown NK, Li X, Gaffrey MJ, Kahraman S, Wei J, Hu J, Basile G, Xiao L, Rana TM, Mathews C, Powers AC, Atkinson MA, Eizirik DL, Dhe-Paganon S, Parent AV, Qian WJ, He C, Kulkarni RN. De Jesus DF, et al. Among authors: hu j. bioRxiv [Preprint]. 2023 Feb 16:2023.02.16.528701. doi: 10.1101/2023.02.16.528701. bioRxiv. 2023. PMID: 36824909 Free PMC article. Updated. Preprint.
Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN. El Ouaamari A, et al. Among authors: hu j. Cell Rep. 2013 Feb 21;3(2):401-10. doi: 10.1016/j.celrep.2013.01.007. Epub 2013 Jan 31. Cell Rep. 2013. PMID: 23375376 Free PMC article.
Soluble factors secreted by T cells promote β-cell proliferation.
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Dirice E, et al. Among authors: hu j. Diabetes. 2014 Jan;63(1):188-202. doi: 10.2337/db13-0204. Epub 2013 Oct 2. Diabetes. 2014. PMID: 24089508 Free PMC article.
SerpinB1 Promotes Pancreatic β Cell Proliferation.
El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. El Ouaamari A, et al. Among authors: hu j. Cell Metab. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015 Dec 15. Cell Metab. 2016. PMID: 26701651 Free PMC article.
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Dirice E, et al. Among authors: hu j. Diabetes. 2016 Jun;65(6):1660-71. doi: 10.2337/db15-1127. Epub 2016 Mar 7. Diabetes. 2016. PMID: 26953159 Free PMC article.
Human duct cells contribute to β cell compensation in insulin resistance.
Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Dirice E, et al. Among authors: hu j. JCI Insight. 2019 Apr 18;4(8):e99576. doi: 10.1172/jci.insight.99576. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996131 Free PMC article.
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Dirice E, et al. Among authors: hu j. Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6. Nat Metab. 2019. PMID: 31423480 Free PMC article.
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