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Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4.
Haider A, Deng X, Mastromihalis O, Pfister SK, Jeppesen TE, Xiao Z, Pham V, Sun S, Rong J, Zhao C, Chen J, Li Y, Connors TR, Davenport AT, Daunais JB, Hosseini V, Ran W, Christopoulos A, Wang L, Valant C, Liang SH. Haider A, et al. Among authors: pham v. Acta Pharm Sin B. 2023 Jan;13(1):213-226. doi: 10.1016/j.apsb.2022.07.008. Epub 2022 Jul 21. Acta Pharm Sin B. 2023. PMID: 36815036 Free PMC article.
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon.
DiCello JJ, Carbone SE, Saito A, Rajasekhar P, Ceredig RA, Pham V, Valant C, Christopoulos A, Veldhuis NA, Canals M, Massotte D, Poole DP. DiCello JJ, et al. Among authors: pham v. Cell Mol Gastroenterol Hepatol. 2020;9(3):465-483. doi: 10.1016/j.jcmgh.2019.11.006. Epub 2019 Nov 20. Cell Mol Gastroenterol Hepatol. 2020. PMID: 31759144 Free PMC article.
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.
DiCello JJ, Carbone SE, Saito A, Pham V, Szymaszkiewicz A, Gondin AB, Alvi S, Marique K, Shenoy P, Veldhuis NA, Fichna J, Canals M, Christopoulos A, Valant C, Poole DP. DiCello JJ, et al. Among authors: pham v. Am J Physiol Gastrointest Liver Physiol. 2022 Jan 1;322(1):G66-G78. doi: 10.1152/ajpgi.00297.2021. Epub 2021 Nov 10. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 34755545 Free article.
Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: pham v. Nat Chem Biol. 2023 Jul;19(7):805-814. doi: 10.1038/s41589-022-01247-5. Epub 2023 Feb 13. Nat Chem Biol. 2023. PMID: 36782010 Free PMC article.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: pham v. Nat Chem Biol. 2023 Apr;19(4):529. doi: 10.1038/s41589-023-01297-3. Nat Chem Biol. 2023. PMID: 36879062 Free PMC article. No abstract available.
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Nawaratne V, Leach K, van der Westhuizen ET, Khajehali E, Liang YL, Glukhova A, Wootten D, Lindsley CW, Tobin A, Sexton P, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM. Vuckovic Z, et al. Among authors: pham v. Elife. 2023 May 30;12:e83477. doi: 10.7554/eLife.83477. Elife. 2023. PMID: 37248726 Free PMC article.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Among authors: pham v. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.
982 results