Williams NS - Search Results

1

Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.

Sun Y, Ranjan A, Tisdale R, Ma SC, Park S, Haire M, Heu J, Morairty SR, Wang X, Rosenbaum DM, Williams NS, De Brabander JK, Kilduff TS. Sun Y, et al. Among authors: williams ns. J Sleep Res. 2023 Aug;32(4):e13839. doi: 10.1111/jsr.13839. Epub 2023 Feb 20. J Sleep Res. 2023. PMID: 36808670

2

Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products.

Jiang X, Williams N, De Brabander JK. Jiang X, et al. Org Lett. 2007 Jan 18;9(2):227-30. doi: 10.1021/ol062656o. Org Lett. 2007. PMID: 17217271 Free PMC article.

3

Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. MacMillan KS, et al. Among authors: williams ns. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6. J Am Chem Soc. 2011. PMID: 21210688 Free PMC article.

4

Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

Wu CY, Feng Y, Cardenas ER, Williams N, Floreancig PE, De Brabander JK, Roth MG. Wu CY, et al. J Am Chem Soc. 2012 Nov 21;134(46):18998-9003. doi: 10.1021/ja3057002. Epub 2012 Nov 13. J Am Chem Soc. 2012. PMID: 23088155 Free PMC article.

5

Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer.

Kim HS, Mendiratta S, Kim J, Pecot CV, Larsen JE, Zubovych I, Seo BY, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs JE, Wei S, Peyton M, Williams N, Gazdar AF, Posner BA, Brekken RA, Sood AK, Deberardinis RJ, Roth MG, Minna JD, White MA. Kim HS, et al. Cell. 2013 Oct 24;155(3):552-66. doi: 10.1016/j.cell.2013.09.041. Epub 2013 Oct 24. Cell. 2013. PMID: 24243015 Free PMC article.

6

Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors.

Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ. Chau V, et al. Among authors: williams ns. Cancer Res. 2014 Jan 15;74(2):586-97. doi: 10.1158/0008-5472.CAN-13-1934. Epub 2013 Nov 27. Cancer Res. 2014. PMID: 24285727 Free PMC article.

7

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Zhang L, et al. Among authors: williams ns. Sci Transl Med. 2016 Oct 19;8(361):361ra140. doi: 10.1126/scitranslmed.aaf8127. Sci Transl Med. 2016. PMID: 27798265 Free PMC article.

8

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma.

Eskiocak B, McMillan EA, Mendiratta S, Kollipara RK, Zhang H, Humphries CG, Wang C, Garcia-Rodriguez J, Ding M, Zaman A, Rosales TI, Eskiocak U, Smith MP, Sudderth J, Komurov K, Deberardinis RJ, Wellbrock C, Davies MA, Wargo JA, Yu Y, De Brabander JK, Williams NS, Chin L, Rizos H, Long GV, Kittler R, White MA. Eskiocak B, et al. Among authors: williams ns. Cancer Discov. 2017 Aug;7(8):832-851. doi: 10.1158/2159-8290.CD-16-0955. Epub 2017 Apr 28. Cancer Discov. 2017. PMID: 28455392 Free PMC article.

9

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.

Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6. Nature. 2019. PMID: 30842654 Free PMC article.

10

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).

Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK. Wang W, et al. Among authors: williams ns. J Med Chem. 2019 May 23;62(10):5217-5241. doi: 10.1021/acs.jmedchem.9b00532. Epub 2019 May 9. J Med Chem. 2019. PMID: 31070915 Free PMC article.

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