Wang X - Search Results

1

Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice.

Sun Y, Ranjan A, Tisdale R, Ma SC, Park S, Haire M, Heu J, Morairty SR, Wang X, Rosenbaum DM, Williams NS, De Brabander JK, Kilduff TS. Sun Y, et al. Among authors: wang x. J Sleep Res. 2023 Aug;32(4):e13839. doi: 10.1111/jsr.13839. Epub 2023 Feb 20. J Sleep Res. 2023. PMID: 36808670

2

A trimethoprim derivative impedes antibiotic resistance evolution.

Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E. Manna MS, et al. Among authors: wang x. Nat Commun. 2021 May 19;12(1):2949. doi: 10.1038/s41467-021-23191-z. Nat Commun. 2021. PMID: 34011959 Free PMC article.

3

Development of a biomarker to monitor target engagement after treatment with dihydroorotate dehydrogenase inhibitors.

Pontikos MA, Leija C, Zhao Z, Wang X, Kilgore J, Tornesi B, Adenmatten N, Phillips MA, Williams NS. Pontikos MA, et al. Among authors: wang x. Biochem Pharmacol. 2022 Oct;204:115237. doi: 10.1016/j.bcp.2022.115237. Epub 2022 Aug 31. Biochem Pharmacol. 2022. PMID: 36055381 Free PMC article.

4

Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction.

Dong X, Liang Q, Pan YZ, Wang X, Kuo YC, Chiang WC, Zhang X, Williams NS, Rizo J, Levine B, De Brabander JK. Dong X, et al. Among authors: wang x. ACS Med Chem Lett. 2022 Aug 12;13(9):1510-1516. doi: 10.1021/acsmedchemlett.2c00309. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105331 Free PMC article.

5

Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration.

Hu B, Toda K, Wang X, Antczak MI, Smith J, Geboers S, Nishikawa G, Li H, Dawson D, Fink S, Desai AB, Williams NS, Markowitz SD, Ready JM. Hu B, et al. Among authors: wang x. J Med Chem. 2022 Nov 24;65(22):15327-15343. doi: 10.1021/acs.jmedchem.2c01299. Epub 2022 Nov 2. J Med Chem. 2022. PMID: 36322935 Free PMC article.

6

Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.

Nguyen TP, Wang W, Sternisha AC, Corley CD, Wang HL, Wang X, Ortiz F, Lim SK, Abdullah KG, Parada LF, Williams NS, McBrayer SK, McDonald JG, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: wang x, wang w, wang hl. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. doi: 10.1016/j.chembiol.2023.01.005. Epub 2023 Feb 8. Cell Chem Biol. 2023. PMID: 36758549 Free PMC article.

7

Orthogonal Hydroxyl Functionalization of cGAMP Confers Metabolic Stability and Enables Antibody Conjugation.

Lu Y, You L, Li L, Kilgore JA, Liu S, Wang X, Dai Y, Wei Q, Shi H, Han L, Sun L, Chen ZJ, Zhang X, Williams NS, Chen C. Lu Y, et al. Among authors: wang x. ACS Cent Sci. 2023 Nov 15;9(12):2298-2305. doi: 10.1021/acscentsci.3c01122. eCollection 2023 Dec 27. ACS Cent Sci. 2023. PMID: 38161369 Free PMC article.

8

Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines.

Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X, Chandrasekaran P, Williams NS, Rosenbaum DM, De Brabander JK. Wang W, et al. Among authors: wang x. Bioorg Med Chem Lett. 2024 Feb 1;99:129624. doi: 10.1016/j.bmcl.2024.129624. Epub 2024 Jan 23. Bioorg Med Chem Lett. 2024. PMID: 38272190

9

Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance.

Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Rodrigues M, et al. Among authors: wang x. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. Cell Host Microbe. 2024. PMID: 38359828

10

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase.

Winterton SE, Capota E, Wang X, Chen H, Mallipeddi PL, Williams NS, Posner BA, Nijhawan D, Ready JM. Winterton SE, et al. Among authors: wang x. J Med Chem. 2018 Jun 28;61(12):5199-5221. doi: 10.1021/acs.jmedchem.8b00052. Epub 2018 Jun 19. J Med Chem. 2018. PMID: 29869888 Free PMC article.

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