Sheng L - Search Results

1

The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study.

Yang G, Jena PK, Hu Y, Sheng L, Chen SY, Slupsky CM, Davis R, Tepper CG, Wan YY. Yang G, et al. Among authors: sheng l. Biomark Res. 2023 Feb 18;11(1):20. doi: 10.1186/s40364-023-00458-9. Biomark Res. 2023. PMID: 36803569 Free PMC article.

2

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation.

Sheng L, Jena PK, Liu HX, Kalanetra KM, Gonzalez FJ, French SW, Krishnan VV, Mills DA, Wan YY. Sheng L, et al. Sci Rep. 2017 May 11;7(1):1748. doi: 10.1038/s41598-017-01576-9. Sci Rep. 2017. PMID: 28496104 Free PMC article.

3

Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment.

Jena PK, Sheng L, Liu HX, Kalanetra KM, Mirsoian A, Murphy WJ, French SW, Krishnan VV, Mills DA, Wan YY. Jena PK, et al. Among authors: sheng l. Am J Pathol. 2017 Aug;187(8):1800-1813. doi: 10.1016/j.ajpath.2017.04.019. Epub 2017 Jul 12. Am J Pathol. 2017. PMID: 28711154 Free PMC article.

4

Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation.

Sheng L, Jena PK, Hu Y, Liu HX, Nagar N, Kalanetra KM, French SW, French SW, Mills DA, Wan YY. Sheng L, et al. J Pathol. 2017 Dec;243(4):431-441. doi: 10.1002/path.4983. Epub 2017 Nov 1. J Pathol. 2017. PMID: 28892150 Free PMC article.

5

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.

Jena PK, Sheng L, Di Lucente J, Jin LW, Maezawa I, Wan YY. Jena PK, et al. Among authors: sheng l. FASEB J. 2018 May;32(5):2866-2877. doi: 10.1096/fj.201700984RR. Epub 2018 Jan 10. FASEB J. 2018. PMID: 29401580 Free PMC article.

Together, dysregulated BA synthesis and dysbiosis were accompanied by systemic inflammation, microglial activation, and reduced neuroplasticity induced by WD.-Jena, P. K., Sheng, L., Di Lucente, J., Jin, L.-W., Maezawa, I., Wan, Y.-J. Y. ...

Together, dysregulated BA synthesis and dysbiosis were accompanied by systemic inflammation, microglial activation, and reduced neuroplastic …

6

Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models.

Jena PK, Sheng L, Nagar N, Wu C, Barile D, Mills DA, Wan YY. Jena PK, et al. Among authors: sheng l. J Nutr Biochem. 2018 Jul;57:246-254. doi: 10.1016/j.jnutbio.2018.04.007. Epub 2018 Apr 25. J Nutr Biochem. 2018. PMID: 29800811 Free PMC article.

7

Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.

Sheng L, Jena PK, Liu HX, Hu Y, Nagar N, Bronner DN, Settles ML, Bäumler AJ, Wan YY. Sheng L, et al. FASEB J. 2018 Jun 8;32(12):fj201800370R. doi: 10.1096/fj.201800370R. Online ahead of print. FASEB J. 2018. PMID: 29882708 Free PMC article.

Together, EGCG shifts gut microbiota and regulates BA signaling thereby having a metabolic beneficial effect.-Sheng, L., Jena, P. K., Liu, H.-X., Hu, Y., Nagar, N., Bronner, D. N., Settles, M. L., Baumler, A. J. Wan, Y.-J. Y. Obesity treatment by epigallocate …

Together, EGCG shifts gut microbiota and regulates BA signaling thereby having a metabolic beneficial effect.-Sheng, L., Jena, …

8

The effect of synbiotics Bifidobacterium infantis and milk oligosaccharides on shaping gut microbiota community structure and NASH treatment.

Jena PK, Sheng L, Nagar N, Wu C, Barile D, Mills DA, Wan YY. Jena PK, et al. Among authors: sheng l. Data Brief. 2018 May 24;19:1025-1029. doi: 10.1016/j.dib.2018.05.127. eCollection 2018 Aug. Data Brief. 2018. PMID: 29900399 Free PMC article.

9

RARβ acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.

Hu Y, French SW, Chau T, Liu HX, Sheng L, Wei F, Stondell J, Garcia JC, Du Y, Bowlus CL, Wan YY. Hu Y, et al. Among authors: sheng l. FASEB J. 2019 Feb;33(2):2314-2326. doi: 10.1096/fj.201801390R. Epub 2018 Sep 25. FASEB J. 2019. PMID: 30252536 Free PMC article.

Results from this study revealed a novel anticancer mechanism of RARbeta via miR-22 induction to epigenetically regulate itself and NUR77, providing a promising cancer treatment modality using miR-22 and its inducers.-Hu, Y., French, S. W., Chau, T., Liu, H.-X., Sheng, …

Results from this study revealed a novel anticancer mechanism of RARbeta via miR-22 induction to epigenetically regulate itself and NUR77, p …

10

A Western Diet, but Not a High-Fat and Low-Sugar Diet, Predisposes Mice to Enhanced Susceptibility to Imiquimod-Induced Psoriasiform Dermatitis.

Yu S, Wu X, Zhou Y, Sheng L, Jena PK, Han D, Wan YJY, Hwang ST. Yu S, et al. Among authors: sheng l. J Invest Dermatol. 2019 Jun;139(6):1404-1407. doi: 10.1016/j.jid.2018.12.002. Epub 2018 Dec 17. J Invest Dermatol. 2019. PMID: 30571973 Free PMC article. No abstract available.

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