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The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, Ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. Weisshaar N, et al. Among authors: klein im. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9. Nat Immunol. 2023. PMID: 37813964 Free PMC article.
First report from the German COVID-19 autopsy registry.
von Stillfried S, Bülow RD, Röhrig R, Boor P; German Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators. von Stillfried S, et al. Lancet Reg Health Eur. 2022 Feb 18;15:100330. doi: 10.1016/j.lanepe.2022.100330. eCollection 2022 Apr. Lancet Reg Health Eur. 2022. PMID: 35531493 Free PMC article.
Oncology enters the informatics era.
Klein IM. Klein IM. Am J Manag Care. 2012 Dec;18(5 Spec No.):SP218-21. Am J Manag Care. 2012. PMID: 23301710 Free article. Review. No abstract available.
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