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Development and validation of LC-MS/MS methods for the simultaneous quantification of sofosbuvir and its major metabolite (GS-331007) in blood plasma and cerebrospinal and seminal fluid: Application to a pilot clinical trial with a focus on Zika.
Vilhena LS, de Azevedo da Silva AC, Dias da Silva DM, Pinto DP, Coelho EF, de Araújo JFGM, da Silveira GPE, Pereira HM, da Silva LSFV, Estrela Marins RCE, Bortolini RG, Souza TML, Dos Santos VGV, de Assis Nascimento V, Amendoeira FC, da Fonseca LB. Vilhena LS, et al. Among authors: dos santos vgv. Biomed Chromatogr. 2023 May;37(5):e5606. doi: 10.1002/bmc.5606. Epub 2023 Mar 5. Biomed Chromatogr. 2023. PMID: 36797051 Clinical Trial.
Sera of patients infected by earlier lineages of SARS-CoV-2 are capable to neutralize later emerged variants of concern.
Pauvolid-Corrêa A, Caetano BC, Machado AB, Ferreira MA, Valente N, Neves TK, Geraldo K, Motta F, Dos Santos VGV, Grinsztejn B, Siqueira MM, Resende PC. Pauvolid-Corrêa A, et al. Among authors: dos santos vgv. Biol Methods Protoc. 2022 Aug 22;7(1):bpac021. doi: 10.1093/biomethods/bpac021. eCollection 2022. Biol Methods Protoc. 2022. PMID: 36128169 Free PMC article.
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, Goicochea P, Casapía M, Guanira-Carranza JV, Ramirez-Cardich ME, Montoya-Herrera O, Fernández T, Veloso VG, Buchbinder SP, Chariyalertsak S, Schechter M, Bekker LG, Mayer KH, Kallás EG, Amico KR, Mulligan K, Bushman LR, Hance RJ, Ganoza C, Defechereux P, Postle B, Wang F, McConnell JJ, Zheng JH, Lee J, Rooney JF, Jaffe HS, Martinez AI, Burns DN, Glidden DV; iPrEx Study Team. Grant RM, et al. N Engl J Med. 2010 Dec 30;363(27):2587-99. doi: 10.1056/NEJMoa1011205. Epub 2010 Nov 23. N Engl J Med. 2010. PMID: 21091279 Free PMC article. Clinical Trial.