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Co-cultivation is a powerful approach to produce a robust functionally designed synthetic consortium as a live biotherapeutic product (LBP).
Kurt F, Leventhal GE, Spalinger MR, Anthamatten L, Rogalla von Bieberstein P, Menzi C, Reichlin M, Meola M, Rosenthal F, Rogler G, Lacroix C, de Wouters T. Kurt F, et al. Among authors: spalinger mr. Gut Microbes. 2023 Jan-Dec;15(1):2177486. doi: 10.1080/19490976.2023.2177486. Gut Microbes. 2023. PMID: 36794804 Free PMC article.
T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.
Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Tremblay ML, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF. Marchelletta RR, et al. Among authors: spalinger mr. J Clin Invest. 2021 Sep 1;131(17):e138230. doi: 10.1172/JCI138230. J Clin Invest. 2021. PMID: 34623320 Free PMC article.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. Bittner ZA, et al. J Exp Med. 2021 Nov 1;218(11):e20201656. doi: 10.1084/jem.20201656. Epub 2021 Sep 23. J Exp Med. 2021. PMID: 34554188 Free PMC article.
Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development.
Haftmann C, Zwicky P, Ingelfinger F, Mair F, Floess S, Riedel R, Durek P, Spalinger MR, Friebel E, Leung BP, Lutz M, Puertas N, Amorim A, Schärli S, Becher B, Kisielow J, Waisman A, Mashreghi MF, Huehn J, Becher B. Haftmann C, et al. Among authors: spalinger mr. Sci Immunol. 2021 Nov 19;6(65):eabf3111. doi: 10.1126/sciimmunol.abf3111. Epub 2021 Nov 19. Sci Immunol. 2021. PMID: 34797691
79 results