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Anionic phospholipids control mechanisms of GPCR-G protein recognition.
Thakur N, Ray AP, Sharp L, Jin B, Duong A, Pour NG, Obeng S, Wijesekara AV, Gao ZG, McCurdy CR, Jacobson KA, Lyman E, Eddy MT. Thakur N, et al. Among authors: obeng s. Nat Commun. 2023 Feb 13;14(1):794. doi: 10.1038/s41467-023-36425-z. Nat Commun. 2023. PMID: 36781870 Free PMC article.
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, León F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Obeng S, et al. J Med Chem. 2020 Jan 9;63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. Epub 2019 Dec 27. J Med Chem. 2020. PMID: 31834797 Free PMC article.
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
Obeng S, Wilkerson JL, León F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londoño C, McCurdy CR, McMahon LR, Hiranita T. Obeng S, et al. J Pharmacol Exp Ther. 2021 Mar;376(3):410-427. doi: 10.1124/jpet.120.000189. Epub 2020 Dec 31. J Pharmacol Exp Ther. 2021. PMID: 33384303 Free PMC article.
Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors.
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR. León F, et al. Among authors: obeng s. J Med Chem. 2021 Sep 23;64(18):13510-13523. doi: 10.1021/acs.jmedchem.1c00726. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34467758 Free PMC article.
In vitro and in vivo pharmacology of kratom.
Hiranita T, Obeng S, Sharma A, Wilkerson JL, McCurdy CR, McMahon LR. Hiranita T, et al. Among authors: obeng s. Adv Pharmacol. 2022;93:35-76. doi: 10.1016/bs.apha.2021.10.001. Epub 2021 Dec 13. Adv Pharmacol. 2022. PMID: 35341571
[No title available]
[No authors listed] [No authors listed] PMID: 35552940
35 results