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Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
Kamens JL, Nance S, Koss C, Xu B, Cotton A, Lam JW, Garfinkle EAR, Nallagatla P, Smith AMR, Mitchell S, Ma J, Currier D, Wright WC, Kavdia K, Pagala VR, Kim W, Wallace LM, Cho JH, Fan Y, Seth A, Twarog N, Choi JK, Obeng EA, Hatley ME, Metzger ML, Inaba H, Jeha S, Rubnitz JE, Peng J, Chen T, Shelat AA, Guy RK, Gruber TA. Kamens JL, et al. Among authors: wright wc. Nat Commun. 2023 Feb 13;14(1):809. doi: 10.1038/s41467-023-36370-x. Nat Commun. 2023. PMID: 36781850 Free PMC article.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Wang J, Buchman CD, Seetharaman J, Miller DJ, Huber AD, Wu J, Chai SC, Garcia-Maldonado E, Wright WC, Chenge J, Chen T. Wang J, et al. Among authors: wright wc. J Am Chem Soc. 2021 Nov 10;143(44):18467-18480. doi: 10.1021/jacs.1c07066. Epub 2021 Oct 14. J Am Chem Soc. 2021. PMID: 34648292 Free PMC article.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB 3rd, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. Pan M, et al. Among authors: wright wc. Nat Commun. 2021 Nov 9;12(1):6468. doi: 10.1038/s41467-021-26640-x. Nat Commun. 2021. PMID: 34753908 Free PMC article.
56 results