The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N.
Silbernagel N, et al. Among authors: baukrowitz t.
FASEB J. 2018 Nov;32(11):6159-6173. doi: 10.1096/fj.201800246R. Epub 2018 Jun 7.
FASEB J. 2018.
PMID: 29879376
Free PMC article.
Severe cardiac bradycardias in VAPB-deficient zebrafish and VAPB(-/-) mice highlight that VAPB physiologically serves to increase cardiac pacemaker currents. An altered T-wave morphology observed in the ECGs of VAPB(-/-) mice supports the recently proposed role of HCN chan …
Severe cardiac bradycardias in VAPB-deficient zebrafish and VAPB(-/-) mice highlight that VAPB physiologically serves to increase cardiac pa …