Johnson OT - Search Results

1

Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models.

Xu P, Yang JC, Ning S, Chen B, Nip C, Wei Q, Liu L, Johnson OT, Gao AC, Gestwicki JE, Evans CP, Liu C. Xu P, et al. Among authors: johnson ot. Pharmacol Res. 2023 Mar;189:106692. doi: 10.1016/j.phrs.2023.106692. Epub 2023 Feb 10. Pharmacol Res. 2023. PMID: 36773708 Free PMC article.

2

Chemical validation of a druggable site on Hsp27/HSPB1 using in silico solvent mapping and biophysical methods.

Makley LN, Johnson OT, Ghanakota P, Rauch JN, Osborn D, Wu TS, Cierpicki T, Carlson HA, Gestwicki JE. Makley LN, et al. Among authors: johnson ot. Bioorg Med Chem. 2021 Mar 15;34:115990. doi: 10.1016/j.bmc.2020.115990. Epub 2021 Jan 24. Bioorg Med Chem. 2021. PMID: 33549906 Free PMC article.

3

Two distinct classes of cochaperones compete for the EEVD motif in heat shock protein 70 to tune its chaperone activities.

Johnson OT, Nadel CM, Carroll EC, Arhar T, Gestwicki JE. Johnson OT, et al. J Biol Chem. 2022 Mar;298(3):101697. doi: 10.1016/j.jbc.2022.101697. Epub 2022 Feb 9. J Biol Chem. 2022. PMID: 35148989 Free PMC article.

4

Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.

Hong SK, Starenki D, Johnson OT, Gestwicki JE, Park JI. Hong SK, et al. Among authors: johnson ot. Int J Mol Sci. 2022 Jan 19;23(3):1063. doi: 10.3390/ijms23031063. Int J Mol Sci. 2022. PMID: 35162987 Free PMC article.

5

Multivalent protein-protein interactions are pivotal regulators of eukaryotic Hsp70 complexes.

Johnson OT, Gestwicki JE. Johnson OT, et al. Cell Stress Chaperones. 2022 Jul;27(4):397-415. doi: 10.1007/s12192-022-01281-1. Epub 2022 Jun 7. Cell Stress Chaperones. 2022. PMID: 35670950 Free PMC article. Review.

6

Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry.

Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE. Wu T, et al. Among authors: johnson ot. bioRxiv [Preprint]. 2023 Jan 28:2023.01.23.525251. doi: 10.1101/2023.01.23.525251. bioRxiv. 2023. PMID: 36747624 Free PMC article. Updated. Preprint.

7

Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.

Echtenkamp FJ, Ishida R, Rivera-Marquez GM, Maisiak M, Johnson OT, Shrimp JH, Sinha A, Ralph SJ, Nisbet I, Cherukuri MK, Gestwicki JE, Neckers LM. Echtenkamp FJ, et al. Among authors: johnson ot. PNAS Nexus. 2023 Apr 3;2(4):pgad115. doi: 10.1093/pnasnexus/pgad115. eCollection 2023 Apr. PNAS Nexus. 2023. PMID: 37091547 Free PMC article.

8

A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.

Tanaka M, Fujikawa R, Sekiguchi T, Hernandez J, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Hoang Trung H, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE, Kuramoto T. Tanaka M, et al. Among authors: johnson ot. Front Neurosci. 2024 Feb 6;18:1263724. doi: 10.3389/fnins.2024.1263724. eCollection 2024. Front Neurosci. 2024. PMID: 38384479 Free PMC article.

9

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes.

Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE. Wu T, et al. Among authors: johnson ot. Nat Biotechnol. 2024 May 14. doi: 10.1038/s41587-024-02158-7. Online ahead of print. Nat Biotechnol. 2024. PMID: 38744946

10

Gene function annotations for the maize NAM founder lines.

Fattel L, Yanarella CF, Ngara B, Johnson OT, Campbell DA, Wimalanathan K, Lawrence-Dill CJ. Fattel L, et al. Among authors: johnson ot. BMC Res Notes. 2024 Jan 2;17(1):9. doi: 10.1186/s13104-023-06668-6. BMC Res Notes. 2024. PMID: 38167110 Free PMC article.

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