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D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells.
Hammon K, Renner K, Althammer M, Voll F, Babl N, Decking SM, Siska PJ, Matos C, Conejo ZEC, Mendes K, Einwag F, Siegmund H, Iberl S, Berger RS, Dettmer K, Schoenmehl R, Brochhausen C, Herr W, Oefner PJ, Rehli M, Thomas S, Kreutz M. Hammon K, et al. Among authors: siska pj. Haematologica. 2024 Jan 18. doi: 10.3324/haematol.2023.283597. Online ahead of print. Haematologica. 2024. PMID: 38235501 Free article.
MCT4 blockade increases the efficacy of immune checkpoint blockade.
Babl N, Decking SM, Voll F, Althammer M, Sala-Hojman A, Ferretti R, Korf C, Schmidl C, Schmidleithner L, Nerb B, Matos C, Koehl GE, Siska P, Bruss C, Kellermeier F, Dettmer K, Oefner PJ, Wichland M, Ugele I, Bohr C, Herr W, Ramaswamy S, Heinrich T, Herhaus C, Kreutz M, Renner K. Babl N, et al. Among authors: siska p. J Immunother Cancer. 2023 Oct;11(10):e007349. doi: 10.1136/jitc-2023-007349. J Immunother Cancer. 2023. PMID: 37880183 Free PMC article.
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8+ T cells.
Riegel D, Romero-Fernández E, Simon M, Adenugba AR, Singer K, Mayr R, Weber F, Kleemann M, Imbusch CD, Kreutz M, Brors B, Ugele I, Werner JM, Siska PJ, Schmidl C. Riegel D, et al. Among authors: siska pj. Mol Cell. 2023 Feb 16;83(4):622-636.e10. doi: 10.1016/j.molcel.2022.12.029. Epub 2023 Jan 18. Mol Cell. 2023. PMID: 36657444 Free article.
101 results