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An E1-E2 fusion protein primes antiviral immune signalling in bacteria.
Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT. Ledvina HE, et al. Among authors: whiteley at. Nature. 2023 Apr;616(7956):319-325. doi: 10.1038/s41586-022-05647-4. Epub 2023 Feb 8. Nature. 2023. PMID: 36755092 Free PMC article.
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity.
Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Lau RK, et al. Among authors: whiteley at. Mol Cell. 2020 Feb 20;77(4):723-733.e6. doi: 10.1016/j.molcel.2019.12.010. Epub 2020 Jan 10. Mol Cell. 2020. PMID: 31932164 Free PMC article.
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Whiteley AT, et al. Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20. Nature. 2019. PMID: 30787435 Free PMC article.
Bacterial NLR-related proteins protect against phage.
Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT. Kibby EM, et al. Among authors: whiteley at. Cell. 2023 May 25;186(11):2410-2424.e18. doi: 10.1016/j.cell.2023.04.015. Epub 2023 May 8. Cell. 2023. PMID: 37160116 Free PMC article.
CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.
Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. Lowey B, et al. Among authors: whiteley at. Cell. 2020 Jul 9;182(1):38-49.e17. doi: 10.1016/j.cell.2020.05.019. Epub 2020 Jun 15. Cell. 2020. PMID: 32544385 Free PMC article.
26 results