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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Ledsgaard L, Wade J, Jenkins TP, Boddum K, Oganesyan I, Harrison JA, Villar P, Leah RA, Zenobi R, Schoffelen S, Voldborg B, Ljungars A, McCafferty J, Lomonte B, Gutiérrez JM, Laustsen AH, Karatt-Vellatt A. Ledsgaard L, et al. Among authors: schoffelen s. Nat Commun. 2023 Feb 8;14(1):682. doi: 10.1038/s41467-023-36393-4. Nat Commun. 2023. PMID: 36755049 Free PMC article.
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.
Sørensen CV, Fernández J, Adams AC, Wildenauer HHK, Schoffelen S, Ledsgaard L, Pucca MB, Fiebig M, Cerni FA, Tulika T, Voldborg BG, Karatt-Vellatt A, Morth JP, Ljungars A, Grav LM, Lomonte B, Laustsen AH. Sørensen CV, et al. Among authors: schoffelen s. Nat Commun. 2024 Jan 16;15(1):173. doi: 10.1038/s41467-023-42624-5. Nat Commun. 2024. PMID: 38228619 Free PMC article.
In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model.
Benard-Valle M, Wouters Y, Ljungars A, Nguyen GTT, Ahmadi S, Ebersole TW, Dahl CH, Guadarrama-Martínez A, Jeppesen F, Eriksen H, Rodríguez-Barrera G, Boddum K, Jenkins TP, Bjørn SP, Schoffelen S, Voldborg BG, Alagón A, Laustsen AH. Benard-Valle M, et al. Among authors: schoffelen s. Nat Commun. 2024 May 21;15(1):4310. doi: 10.1038/s41467-024-48539-z. Nat Commun. 2024. PMID: 38773068 Free PMC article.
Glycoengineered recombinant alpha1-antitrypsin results in comparable in vitro and in vivo activities to human plasma-derived protein.
Rocamora F, Schoffelen S, Arnsdorf J, Toth EA, Abdul Y, Cleveland TE 4th, Bjørn SP, Wu MYM, McElvaney NG, Voldborg BGR, Fuerst TR, Lewis NE. Rocamora F, et al. Among authors: schoffelen s. bioRxiv [Preprint]. 2024 Mar 30:2024.03.27.587088. doi: 10.1101/2024.03.27.587088. bioRxiv. 2024. PMID: 38585818 Free PMC article. Preprint.
Selective Acylation of Proteins at Gly and Lys in His Tags.
Jensen KJ, Thygesen MB, Sørensen KK, Wu S, Treiberg T, Schoffelen S. Jensen KJ, et al. Among authors: schoffelen s. Chembiochem. 2022 Dec 16;23(24):e202200359. doi: 10.1002/cbic.202200359. Epub 2022 Sep 14. Chembiochem. 2022. PMID: 35984670
33 results