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TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy.
Nguyen T, Carrieri FA, Connis N, Lafargue A, Chang J, Chan A, Shetty AC, Song Y, Hoang T, Jagtap S, Chowdhury DD, Khan MA, Gabrielson KL, Rezaee M, Torres-Ayuso P, Brognard J, Hann CL, Tran PT. Nguyen T, et al. Among authors: connis n. Mol Cancer Ther. 2024 Apr 27. doi: 10.1158/1535-7163.MCT-23-0412. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38670554
Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS.
Wang X, Raman N, Lemtiri-Chlieh G, Chang J, Jagtap S, Chowdhury DD, Ballew M, Carrieri FA, Nguyen T, Nugent K, Peck T, Levine MS, Chan A, Lam C, Malek R, Hoang T, Phillips R, Cheng Z, Taparra K, Connis N, Hann CL, Holland A, Tran PT, Lafargue A, Wang H. Wang X, et al. Among authors: connis n. Mol Cancer Ther. 2023 Apr 3;22(4):519-528. doi: 10.1158/1535-7163.MCT-22-0191. Mol Cancer Ther. 2023. PMID: 36752776 Free PMC article.
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
Khan S, Kellish P, Connis N, Thummuri D, Wiegand J, Zhang P, Zhang X, Budamagunta V, Hua N, Yang Y, De U, Jin L, Zhang W, Zheng G, Hromas R, Hann C, Zajac-Kaye M, Kaye FJ, Zhou D. Khan S, et al. Among authors: connis n. Cell Death Discov. 2023 Jan 2;9(1):1. doi: 10.1038/s41420-022-01296-8. Cell Death Discov. 2023. PMID: 36588105 Free PMC article.
AZD8055 enhances in vivo efficacy of afatinib in chordomas.
Zhao T, Siu IM, Williamson T, Zhang H, Ji C, Burger PC, Connis N, Ruzevick J, Xia M, Cottone L, Flanagan AM, Hann CL, Gallia GL. Zhao T, et al. Among authors: connis n. J Pathol. 2021 Sep;255(1):72-83. doi: 10.1002/path.5739. Epub 2021 Jul 28. J Pathol. 2021. PMID: 34124783 Free PMC article.
Rapamycin rescues ABT-737 efficacy in small cell lung cancer.
Gardner EE, Connis N, Poirier JT, Cope L, Dobromilskaya I, Gallia GL, Rudin CM, Hann CL. Gardner EE, et al. Among authors: connis n. Cancer Res. 2014 May 15;74(10):2846-56. doi: 10.1158/0008-5472.CAN-13-3460. Epub 2014 Mar 10. Cancer Res. 2014. PMID: 24614082 Free PMC article.
Erlotinib inhibits growth of a patient-derived chordoma xenograft.
Siu IM, Ruzevick J, Zhao Q, Connis N, Jiao Y, Bettegowda C, Xia X, Burger PC, Hann CL, Gallia GL. Siu IM, et al. Among authors: connis n. PLoS One. 2013 Nov 15;8(11):e78895. doi: 10.1371/journal.pone.0078895. eCollection 2013. PLoS One. 2013. PMID: 24260133 Free PMC article.
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