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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ. Crompton M, et al. Among authors: harper sj. JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164. JCI Insight. 2023. PMID: 36749631 Free PMC article. Clinical Trial.
Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations.
Finch NC, Fawaz SS, Neal CR, Butler MJ, Lee VK, Salmon AJ, Lay AC, Stevens M, Dayalan L, Band H, Mellor HH, Harper SJ, Shima DT, Welsh GI, Foster RR, Satchell SC. Finch NC, et al. Among authors: harper sj. J Am Soc Nephrol. 2022 Jun;33(6):1120-1136. doi: 10.1681/ASN.2021030294. Epub 2022 Mar 15. J Am Soc Nephrol. 2022. PMID: 35292439 Free PMC article.
Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy.
Oltean S, Qiu Y, Ferguson JK, Stevens M, Neal C, Russell A, Kaura A, Arkill KP, Harris K, Symonds C, Lacey K, Wijeyaratne L, Gammons M, Wylie E, Hulse RP, Alsop C, Cope G, Damodaran G, Betteridge KB, Ramnath R, Satchell SC, Foster RR, Ballmer-Hofer K, Donaldson LF, Barratt J, Baelde HJ, Harper SJ, Bates DO, Salmon AH. Oltean S, et al. Among authors: harper sj. J Am Soc Nephrol. 2015 Aug;26(8):1889-904. doi: 10.1681/ASN.2014040350. Epub 2014 Dec 26. J Am Soc Nephrol. 2015. PMID: 25542969 Free PMC article.
Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction.
Salmon AH, Ferguson JK, Burford JL, Gevorgyan H, Nakano D, Harper SJ, Bates DO, Peti-Peterdi J. Salmon AH, et al. Among authors: harper sj. J Am Soc Nephrol. 2012 Aug;23(8):1339-50. doi: 10.1681/ASN.2012010017. Epub 2012 Jul 12. J Am Soc Nephrol. 2012. PMID: 22797190 Free PMC article.
VEGF-C promotes survival in podocytes.
Foster RR, Satchell SC, Seckley J, Emmett MS, Joory K, Xing CY, Saleem MA, Mathieson PW, Bates DO, Harper SJ. Foster RR, et al. Among authors: harper sj. Am J Physiol Renal Physiol. 2006 Jul;291(1):F196-207. doi: 10.1152/ajprenal.00431.2005. Epub 2006 Mar 8. Am J Physiol Renal Physiol. 2006. PMID: 16525158 Free article.
231 results