Vocadlo DJ - Search Results

1

Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry.

Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE. Wu T, et al. Among authors: vocadlo dj. bioRxiv [Preprint]. 2023 Jan 28:2023.01.23.525251. doi: 10.1101/2023.01.23.525251. bioRxiv. 2023. PMID: 36747624 Free PMC article. Updated. Preprint.

2

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease.

Williams D, Glasstetter LM, Jong TT, Kapoor A, Zhu S, Zhu Y, Gehrlein A, Vocadlo DJ, Jagasia R, Marugan JJ, Sidransky E, Henderson MJ, Chen Y. Williams D, et al. Among authors: vocadlo dj. bioRxiv [Preprint]. 2024 Mar 27:2024.03.22.586364. doi: 10.1101/2024.03.22.586364. bioRxiv. 2024. PMID: 38712038 Free PMC article. Preprint.

3

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes.

Wu T, Yu JC, Suresh A, Gale-Day ZJ, Alteen MG, Woo AS, Millbern Z, Johnson OT, Carroll EC, Partch CL, Fourches D, Vinueza NR, Vocadlo DJ, Gestwicki JE. Wu T, et al. Among authors: vocadlo dj. Nat Biotechnol. 2024 May 14. doi: 10.1038/s41587-024-02158-7. Online ahead of print. Nat Biotechnol. 2024. PMID: 38744946

4

Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics.

Calvelo M, Males A, Alteen MG, Willems LI, Vocadlo DJ, Davies GJ, Rovira C. Calvelo M, et al. Among authors: vocadlo dj. ACS Catal. 2023 Oct 10;13(20):13672-13678. doi: 10.1021/acscatal.3c02378. eCollection 2023 Oct 20. ACS Catal. 2023. PMID: 37969138 Free PMC article.

5

Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases.

Pratt MR, Vocadlo DJ. Pratt MR, et al. Among authors: vocadlo dj. J Biol Chem. 2023 Dec;299(12):105411. doi: 10.1016/j.jbc.2023.105411. Epub 2023 Oct 31. J Biol Chem. 2023. PMID: 37918804 Free PMC article. Review.

6

Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo.

Deen MC, Gilormini PA, Vocadlo DJ. Deen MC, et al. Among authors: vocadlo dj. Curr Opin Chem Biol. 2023 Dec;77:102403. doi: 10.1016/j.cbpa.2023.102403. Epub 2023 Oct 17. Curr Opin Chem Biol. 2023. PMID: 37856901 Review.

7

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase.

Alteen MG, Meek RW, Kolappan S, Busmann JA, Cao J, O'Gara Z, Chou Y, Derda R, Davies GJ, Vocadlo DJ. Alteen MG, et al. Among authors: vocadlo dj. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2303690120. doi: 10.1073/pnas.2303690120. Epub 2023 Oct 11. Proc Natl Acad Sci U S A. 2023. PMID: 37819980 Free PMC article.

8

Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons.

Keefe AJ, Gabrych DR, Zhu Y, Vocadlo DJ, Silverman MA. Keefe AJ, et al. Among authors: vocadlo dj. eNeuro. 2023 Oct 10;10(10):ENEURO.0079-23.2023. doi: 10.1523/ENEURO.0079-23.2023. Print 2023 Oct. eNeuro. 2023. PMID: 37816595 Free PMC article.

9

A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.

Zhu S, Deen MC, Zhu Y, Gilormini PA, Chen X, Davis OB, Chin MY, Henry AG, Vocadlo DJ. Zhu S, et al. Among authors: vocadlo dj. Angew Chem Int Ed Engl. 2023 Oct 2;62(40):e202309306. doi: 10.1002/anie.202309306. Epub 2023 Aug 28. Angew Chem Int Ed Engl. 2023. PMID: 37582679

10

A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae.

Bhosale S, Deen MC, Proceviat C, Hettle A, Winter DK, Brockerman J, Levene M, Bennet AJ, Spino C, Boraston AB, Vocadlo DJ. Bhosale S, et al. Among authors: vocadlo dj. ACS Chem Biol. 2023 Aug 18;18(8):1730-1737. doi: 10.1021/acschembio.3c00053. Epub 2023 Aug 2. ACS Chem Biol. 2023. PMID: 37531094

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