George R - Search Results

1

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.

Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J. Ismail M, et al. Among authors: george r. Sci Rep. 2023 Feb 2;13(1):1889. doi: 10.1038/s41598-023-28756-0. Sci Rep. 2023. PMID: 36732563 Free PMC article.

2

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.

Fritsch R, de Krijger I, Fritsch K, George R, Reason B, Kumar MS, Diefenbacher M, Stamp G, Downward J. Fritsch R, et al. Among authors: george r. Cell. 2013 May 23;153(5):1050-63. doi: 10.1016/j.cell.2013.04.031. Cell. 2013. PMID: 23706742 Free PMC article.

3

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.

Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A. Morini MF, et al. Among authors: george r. Circ Res. 2018 Jan 19;122(2):231-245. doi: 10.1161/CIRCRESAHA.117.312392. Epub 2017 Dec 12. Circ Res. 2018. PMID: 29233846 Free PMC article.

4

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets.

Cooley R, Kara N, Hui NS, Tart J, Roustan C, George R, Hancock DC, Binkowski BF, Wood KV, Ismail M, Downward J. Cooley R, et al. Among authors: george r. Wellcome Open Res. 2020 Feb 6;5:20. doi: 10.12688/wellcomeopenres.15675.1. eCollection 2020. Wellcome Open Res. 2020. PMID: 32587898 Free PMC article.

5

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization.

Gori I, George R, Purkiss AG, Strohbuecker S, Randall RA, Ogrodowicz R, Carmignac V, Faivre L, Joshi D, Kjær S, Hill CS. Gori I, et al. Among authors: george r. Elife. 2021 Jan 8;10:e63545. doi: 10.7554/eLife.63545. Elife. 2021. PMID: 33416497 Free PMC article.

6

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.

Riou P, Kjær S, Garg R, Purkiss A, George R, Cain RJ, Bineva G, Reymond N, McColl B, Thompson AJ, O'Reilly N, McDonald NQ, Parker PJ, Ridley AJ. Riou P, et al. Among authors: george r. Cell. 2013 Apr 25;153(3):640-53. doi: 10.1016/j.cell.2013.03.044. Cell. 2013. PMID: 23622247 Free PMC article.

7

Targeting the HER3 pseudokinase domain with small molecule inhibitors.

Colomba A, Claus J, Gao F, George R, Fornili A, Cameron AJM. Colomba A, et al. Among authors: george r. Methods Enzymol. 2022;667:455-505. doi: 10.1016/bs.mie.2022.03.044. Epub 2022 Apr 18. Methods Enzymol. 2022. PMID: 35525551

8

RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association.

Goodman KM, Kjær S, Beuron F, Knowles PP, Nawrotek A, Burns EM, Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ. Goodman KM, et al. Among authors: george r. Cell Rep. 2014 Sep 25;8(6):1894-1904. doi: 10.1016/j.celrep.2014.08.040. Epub 2014 Sep 18. Cell Rep. 2014. PMID: 25242331 Free article.

9

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

Suen KM, Lin CC, Seiler C, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST, Ladbury JE. Suen KM, et al. Among authors: george r. Int J Biochem Cell Biol. 2018 Jan;94:89-97. doi: 10.1016/j.biocel.2017.11.014. Epub 2017 Dec 5. Int J Biochem Cell Biol. 2018. PMID: 29208567 Free article.

10

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.

Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE. Ahmed Z, et al. Among authors: george r. Cell Signal. 2010 Jan;22(1):23-33. doi: 10.1016/j.cellsig.2009.08.011. Epub 2009 Sep 6. Cell Signal. 2010. PMID: 19735729

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