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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.
Ismail M, Martin SR, George R, Houghton F, Kelly G, Chaleil RAG, Anastasiou P, Wang X, O'Reilly N, Federico S, Joshi D, Nagaraj H, Cooley R, Hui NS, Molina-Arcas M, Hancock DC, Tavassoli A, Downward J. Ismail M, et al. Among authors: downward j. Sci Rep. 2023 Feb 2;13(1):1889. doi: 10.1038/s41598-023-28756-0. Sci Rep. 2023. PMID: 36732563 Free PMC article.
Phosphatidylinositol-3-OH kinase as a direct target of Ras.
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Rodriguez-Viciana P, et al. Among authors: downward j. Nature. 1994 Aug 18;370(6490):527-32. doi: 10.1038/370527a0. Nature. 1994. PMID: 8052307
Phosphatidylinositol 3' kinase: one of the effectors of Ras.
Rodriguez-Viciana P, Marte BM, Warne PH, Downward J. Rodriguez-Viciana P, et al. Among authors: downward j. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):225-31; discussion 231-2. doi: 10.1098/rstb.1996.0020. Philos Trans R Soc Lond B Biol Sci. 1996. PMID: 8650270 Review.
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.
Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Nicke B, et al. Among authors: downward j. Mol Cell. 2005 Dec 9;20(5):673-85. doi: 10.1016/j.molcel.2005.10.038. Mol Cell. 2005. PMID: 16337592 Free article.
How to fool a wonder drug: truncate and dimerize.
Molina-Arcas M, Downward J. Molina-Arcas M, et al. Among authors: downward j. Cancer Cell. 2012 Jan 17;21(1):7-9. doi: 10.1016/j.ccr.2011.12.017. Cancer Cell. 2012. PMID: 22264784 Free article.
296 results