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Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence.
Razvi E, Whitfield GB, Reichhardt C, Dreifus JE, Willis AR, Gluscencova OB, Gloag ES, Awad TS, Rich JD, da Silva DP, Bond W, Le Mauff F, Sheppard DC, Hatton BD, Stoodley P, Reinke AW, Boulianne GL, Wozniak DJ, Harrison JJ, Parsek MR, Howell PL. Razvi E, et al. NPJ Biofilms Microbiomes. 2023 Feb 2;9(1):7. doi: 10.1038/s41522-023-00375-7. NPJ Biofilms Microbiomes. 2023. PMID: 36732330 Free PMC article.
PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation.
Marmont LS, Whitfield GB, Pfoh R, Williams RJ, Randall TE, Ostaszewski A, Razvi E, Groves RA, Robinson H, Nitz M, Parsek MR, Lewis IA, Whitney JC, Harrison JJ, Howell PL. Marmont LS, et al. Among authors: razvi e. J Biol Chem. 2020 Aug 21;295(34):11949-11962. doi: 10.1074/jbc.RA120.014555. Epub 2020 Jun 29. J Biol Chem. 2020. PMID: 32601062 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33455637
Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.
Razvi E, DiFrancesco BR, Wasney GA, Morrison ZA, Tam J, Auger A, Baker P, Alnabelseya N, Rich JD, Sivarajah P, Whitfield GB, Harrison JJ, Melnyk RA, Nitz M, Howell PL. Razvi E, et al. Microbiol Spectr. 2023 Jun 15;11(3):e0029623. doi: 10.1128/spectrum.00296-23. Epub 2023 Apr 26. Microbiol Spectr. 2023. PMID: 37098898 Free PMC article.
26 results