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732 results

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Page 1
The liver diseases of lipodystrophy: the long-term effect of leptin treatment.
Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P. Safar Zadeh E, et al. Among authors: brown rj. J Hepatol. 2013 Jul;59(1):131-7. doi: 10.1016/j.jhep.2013.02.007. Epub 2013 Feb 21. J Hepatol. 2013. PMID: 23439261 Free PMC article. Clinical Trial.
Effects of Metreleptin in Pediatric Patients With Lipodystrophy.
Brown RJ, Meehan CA, Cochran E, Rother KI, Kleiner DE, Walter M, Gorden P. Brown RJ, et al. J Clin Endocrinol Metab. 2017 May 1;102(5):1511-1519. doi: 10.1210/jc.2016-3628. J Clin Endocrinol Metab. 2017. PMID: 28324110 Free PMC article.
Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.
Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P. Brown RJ, et al. J Clin Invest. 2018 Aug 1;128(8):3504-3516. doi: 10.1172/JCI95476. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29723161 Free PMC article. Clinical Trial.
Visceral fat does not contribute to metabolic disease in lipodystrophy.
Malandrino N, Reynolds JC, Brychta RJ, Chen KY, Auh S, Gharib AM, Startzell M, Cochran EK, Brown RJ. Malandrino N, et al. Among authors: brown rj. Obes Sci Pract. 2019 Jan 24;5(1):75-82. doi: 10.1002/osp4.319. eCollection 2019 Feb. Obes Sci Pract. 2019. PMID: 30847226 Free PMC article.
Leptin decreases de novo lipogenesis in patients with lipodystrophy.
Baykal AP, Parks EJ, Shamburek R, Syed-Abdul MM, Chacko S, Cochran E, Startzell M, Gharib AM, Ouwerkerk R, Abd-Elmoniem KZ, Walter PJ, Walter M, Muniyappa R, Chung ST, Brown RJ. Baykal AP, et al. Among authors: brown rj. JCI Insight. 2020 Jul 23;5(14):e137180. doi: 10.1172/jci.insight.137180. JCI Insight. 2020. PMID: 32573497 Free PMC article.
Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy.
Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Lightbourne M, et al. Among authors: brown rj. J Clin Lipidol. 2022 Nov-Dec;16(6):850-862. doi: 10.1016/j.jacl.2022.06.011. Epub 2022 Sep 22. J Clin Lipidol. 2022. PMID: 36195542 Free PMC article. Clinical Trial.
732 results