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TDP-43 protein interactome informs about perturbed canonical pathways and may help develop personalized medicine approaches for patients with TDP-43 pathology.
Drug Discov Today. 2023 Nov;28(11):103769. doi: 10.1016/j.drudis.2023.103769. Epub 2023 Sep 14.
Drug Discov Today. 2023.
PMID: 37714405
Free PMC article.
Review.
Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology.
Genç B, Nho B, Seung H, Helmold B, Park H, Gözütok Ö, Kim S, Park J, Ye S, Lee H, Lee N, Yu SS, Kim S, Lee J, Özdinler H.
Genç B, et al. Among authors: helmold b.
Gene Ther. 2023 Aug;30(7-8):560-574. doi: 10.1038/s41434-023-00383-4. Epub 2023 Feb 24.
Gene Ther. 2023.
PMID: 36823441
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SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function.
Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH.
Gautam M, et al. Among authors: helmold b.
Neurobiol Dis. 2023 Mar;178:106022. doi: 10.1016/j.nbd.2023.106022. Epub 2023 Jan 27.
Neurobiol Dis. 2023.
PMID: 36716828
Free article.
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NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone.
Genç B, Gautam M, Helmold BR, Koçak N, Günay A, Goshu GM, Silverman RB, Hande Ozdinler P.
Genç B, et al. Among authors: helmold br.
Sci Rep. 2022 Mar 30;12(1):5383. doi: 10.1038/s41598-022-09332-4.
Sci Rep. 2022.
PMID: 35354901
Free PMC article.
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2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma.
Gautam M, Carratore RD, Helmold B, Tessa A, Gozutok O, Chandel N, Idrisoglu H, Bongioanni P, Battini R, Ozdinler PH.
Gautam M, et al. Among authors: helmold b.
Metabolites. 2022 Feb 12;12(2):174. doi: 10.3390/metabo12020174.
Metabolites. 2022.
PMID: 35208248
Free PMC article.
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Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS.
Gozutok O, Helmold BR, Ozdinler PH.
Gozutok O, et al. Among authors: helmold br.
Brain Sci. 2021 Apr 29;11(5):578. doi: 10.3390/brainsci11050578.
Brain Sci. 2021.
PMID: 33947096
Free PMC article.
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