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Impact of surfactants and other body fluids on in vitro activity of a novel β-lactamase inhibitor enmetazobactam in combination with cefepime against clinical isolates of Klebsiella pneumoniae.
Nussbaumer-Pröll A, Eberl S, Belley A, Knechtle P, Huband MD, Huynh HK, Zeitlinger M. Nussbaumer-Pröll A, et al. Among authors: knechtle p. J Antibiot (Tokyo). 2023 Mar;76(3):183-189. doi: 10.1038/s41429-022-00592-w. Epub 2023 Jan 23. J Antibiot (Tokyo). 2023. PMID: 36690707
Development of Broth Microdilution MIC and Disk Diffusion Antimicrobial Susceptibility Test Quality Control Ranges for the Combination of Cefepime and the Novel β-Lactamase Inhibitor Enmetazobactam.
Belley A, Huband MD, Fedler KA, Watters AA, Flamm RK, Shapiro S, Knechtle P. Belley A, et al. Among authors: knechtle p. J Clin Microbiol. 2019 Jul 26;57(8):e00607-19. doi: 10.1128/JCM.00607-19. Print 2019 Aug. J Clin Microbiol. 2019. PMID: 31167844 Free PMC article.
Third-generation cephalosporin resistance in clinical isolates of Enterobacterales collected between 2016-2018 from USA and Europe: genotypic analysis of β-lactamases and comparative in vitro activity of cefepime/enmetazobactam.
Belley A, Morrissey I, Hawser S, Kothari N, Knechtle P. Belley A, et al. Among authors: knechtle p. J Glob Antimicrob Resist. 2021 Jun;25:93-101. doi: 10.1016/j.jgar.2021.02.031. Epub 2021 Mar 18. J Glob Antimicrob Resist. 2021. PMID: 33746112 Free article.
Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum-β-Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae.
Johnson A, McEntee L, Farrington N, Kolamunnage-Dona R, Franzoni S, Vezzelli A, Massimiliano M, Knechtle P, Belley A, Dane A, Drusano G, Das S, Hope W. Johnson A, et al. Among authors: knechtle p. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20. doi: 10.1128/AAC.00180-20. Print 2020 May 21. Antimicrob Agents Chemother. 2020. PMID: 32253209 Free PMC article.
Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.
Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P. Kaye KS, et al. Among authors: knechtle p. JAMA. 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. JAMA. 2022. PMID: 36194218 Free PMC article. Clinical Trial.
Intrapulmonary Pharmacokinetics of Cefepime and Enmetazobactam in Healthy Volunteers: Towards New Treatments for Nosocomial Pneumonia.
Das S, Fitzgerald R, Ullah A, Bula M, Collins AM, Mitsi E, Reine J, Hill H, Rylance J, Ferreira DM, Tripp K, Bertasini A, Franzoni S, Massimiliano M, Lahlou O, Motta P, Barth P, Velicitat P, Knechtle P, Hope W. Das S, et al. Among authors: knechtle p. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01468-20. doi: 10.1128/AAC.01468-20. Print 2020 Dec 16. Antimicrob Agents Chemother. 2020. PMID: 33077666 Free PMC article.
131 results