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Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate.
Bobiļeva O, Bobrovs R, Kaņepe I, Patetko L, Kalniņš G, Šišovs M, Bula AL, Gri Nberga S, Borodušķis MR, Ramata-Stunda A, Rostoks N, Jirgensons A, Ta Rs K, Jaudzems K. Bobiļeva O, et al. ACS Med Chem Lett. 2021 Jun 9;12(7):1102-1107. doi: 10.1021/acsmedchemlett.1c00140. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34257831 Free PMC article.
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, Antonov D, Konda VR, Lindström S, Olanders G, Brandt P, Baranczewski P, Vingsbo Lundberg C, Liepinsh E, Suna E, Jones TA, Mowbray SL, Hughes D, Karlén A. Huseby DL, et al. Among authors: bobileva o. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5. Proc Natl Acad Sci U S A. 2024. PMID: 38579010 Free PMC article.
Small-Molecule Inhibitors of the m7G-RNA Writer METTL1.
Nai F, Flores Espinoza MP, Invernizzi A, Vargas-Rosales PA, Bobileva O, Herok M, Caflisch A. Nai F, et al. Among authors: bobileva o. ACS Bio Med Chem Au. 2023 Dec 12;4(2):100-110. doi: 10.1021/acsbiomedchemau.3c00030. eCollection 2024 Apr 17. ACS Bio Med Chem Au. 2023. PMID: 38645929 Free PMC article.