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Structural Characterization of LRRK2 Inhibitors.
Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A. Gilsbach BK, et al. Among authors: kortholt a. J Med Chem. 2015 May 14;58(9):3751-6. doi: 10.1021/jm5018779. Epub 2015 May 1. J Med Chem. 2015. PMID: 25897865
The small GTPases Ras and Rap1 bind to and control TORC2 activity.
Khanna A, Lotfi P, Chavan AJ, Montaño NM, Bolourani P, Weeks G, Shen Z, Briggs SP, Pots H, Van Haastert PJ, Kortholt A, Charest PG. Khanna A, et al. Among authors: kortholt a. Sci Rep. 2016 May 13;6:25823. doi: 10.1038/srep25823. Sci Rep. 2016. PMID: 27172998 Free PMC article.
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ. Guaitoli G, et al. Among authors: kortholt a. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66. doi: 10.1073/pnas.1523708113. Epub 2016 Jun 29. Proc Natl Acad Sci U S A. 2016. PMID: 27357661 Free PMC article.
The unconventional G-protein cycle of LRRK2 and Roco proteins.
Terheyden S, Nederveen-Schippers LM, Kortholt A. Terheyden S, et al. Among authors: kortholt a. Biochem Soc Trans. 2016 Dec 15;44(6):1611-1616. doi: 10.1042/BST20160224. Biochem Soc Trans. 2016. PMID: 27913669 Review.
73 results