Dubowchik GM - Search Results

1

Structure-activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors.

Luo G, Chen L, Jacutin-Porte S, Han Y, Burton CR, Xiao H, Krause CM, Cao Y, Liu N, Kish K, Lewis HA, Macor JE, Dubowchik GM. Luo G, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2023 Feb 1;81:129143. doi: 10.1016/j.bmcl.2023.129143. Epub 2023 Jan 18. Bioorg Med Chem Lett. 2023. PMID: 36669575

2

Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-beta-lactamase fusion protein.

Vrudhula VM, Kerr DE, Siemers NO, Dubowchik GM, Senter PD. Vrudhula VM, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2003 Feb 10;13(3):539-42. doi: 10.1016/s0960-894x(02)00935-6. Bioorg Med Chem Lett. 2003. PMID: 12565967

3

2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.

Dubowchik GM, Michne JA, Zuev D, Schwartz W, Scola PM, James CA, Ruediger EH, Pin SS, Burris KD, Balanda LA, Gao Q, Wu D, Fung L, Fiedler T, Browman KE, Taber MT, Zhang J. Dubowchik GM, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3997-4000. doi: 10.1016/j.bmcl.2003.08.055. Bioorg Med Chem Lett. 2003. PMID: 14592493

4

Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.

Karageorge GN, Bertenshaw S, Iben L, Xu C, Sarbin N, Gentile A, Dubowchik GM. Karageorge GN, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5881-4. doi: 10.1016/j.bmcl.2004.09.024. Bioorg Med Chem Lett. 2004. PMID: 15501061

5

Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis.

Zuev D, Michne JA, Pin SS, Zhang J, Taber MT, Dubowchik GM. Zuev D, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Jan 17;15(2):431-4. doi: 10.1016/j.bmcl.2004.10.055. Bioorg Med Chem Lett. 2005. PMID: 15603967

6

Stereoselective synthesis of new conformationally restricted analogues of a potent CGRP receptor antagonist.

Zuev D, Michne JA, Huang H, Beno BR, Wu D, Gao Q, Torrente JR, Xu C, Conway CM, Macor JE, Dubowchik GM. Zuev D, et al. Among authors: dubowchik gm. Org Lett. 2005 Jun 9;7(12):2465-8. doi: 10.1021/ol0510062. Org Lett. 2005. PMID: 15932224

7

Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists.

Han X, Pin SS, Burris K, Fung LK, Huang S, Taber MT, Zhang J, Dubowchik GM. Han X, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4029-32. doi: 10.1016/j.bmcl.2005.06.028. Bioorg Med Chem Lett. 2005. PMID: 15982881

8

Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.

Han X, Michne JA, Pin SS, Burris KD, Balanda LA, Fung LK, Fiedler T, Browman KE, Taber MT, Zhang J, Dubowchik GM. Han X, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3870-3. doi: 10.1016/j.bmcl.2005.05.117. Bioorg Med Chem Lett. 2005. PMID: 15990298

9

Regioselective protection at N-2 and derivatization at C-3 of indazoles.

Luo G, Chen L, Dubowchik G. Luo G, et al. J Org Chem. 2006 Jul 7;71(14):5392-5. doi: 10.1021/jo060607j. J Org Chem. 2006. PMID: 16808535

10

An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes.

Han X, Civiello R, Pin SS, Burris K, Balanda LA, Knipe J, Ren S, Fiedler T, Browman KE, Macci R, Taber MT, Zhang J, Dubowchik GM. Han X, et al. Among authors: dubowchik gm. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2026-30. doi: 10.1016/j.bmcl.2007.01.008. Epub 2007 Jan 13. Bioorg Med Chem Lett. 2007. PMID: 17258456

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