Okasha RM - Search Results

1

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels.

Al-Harbi LM, Al-Harbi EA, Okasha RM, El-Eisawy RA, El-Nassag MAA, Mohamed HM, Fouda AM, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Al-Harbi LM, et al. Among authors: okasha rm. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155814. doi: 10.1080/14756366.2022.2155814. J Enzyme Inhib Med Chem. 2023. PMID: 36662632 Free PMC article.

2

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM. Ahmed HEA, et al. Among authors: okasha rm. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503. J Enzyme Inhib Med Chem. 2018. PMID: 29923425 Free PMC article.

3

Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.

Alblewi FF, Okasha RM, Hritani ZM, Mohamed HM, El-Nassag MAA, Halawa AH, Mora A, Fouda AM, Assiri MA, Al-Dies AM, Afifi TH, El-Agrody AM. Alblewi FF, et al. Among authors: okasha rm. Bioorg Chem. 2019 Jun;87:560-571. doi: 10.1016/j.bioorg.2019.03.059. Epub 2019 Mar 22. Bioorg Chem. 2019. PMID: 30928878

4

Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives.

Okasha RM, Albalawi FF, Afifi TH, Fouda AM, Al-Dies AM, El-Agrody AM. Okasha RM, et al. Molecules. 2016 Nov 1;21(11):1450. doi: 10.3390/molecules21111450. Molecules. 2016. PMID: 27809292 Free PMC article.

5

Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Okasha RM, Alblewi FF, Afifi TH, Naqvi A, Fouda AM, Al-Dies AM, El-Agrody AM. Okasha RM, et al. Molecules. 2017 Mar 18;22(3):479. doi: 10.3390/molecules22030479. Molecules. 2017. PMID: 28335470 Free PMC article.

6

Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis.

Alblewi FF, Okasha RM, Eskandrani AA, Afifi TH, Mohamed HM, Halawa AH, Fouda AM, Al-Dies AM, Mora A, El-Agrody AM. Alblewi FF, et al. Among authors: okasha rm. Molecules. 2019 Mar 18;24(6):1060. doi: 10.3390/molecules24061060. Molecules. 2019. PMID: 30889862 Free PMC article.

7

A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules.

Fouda AM, Okasha RM, Alblewi FF, Mora A, Afifi TH, El-Agrody AM. Fouda AM, et al. Among authors: okasha rm. Bioorg Chem. 2020 Jan;95:103549. doi: 10.1016/j.bioorg.2019.103549. Epub 2019 Dec 23. Bioorg Chem. 2020. PMID: 31887476

8

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.

Halawa AH, Eskandrani AA, Elgammal WE, Hassan SM, Hassan AH, Ebrahim HY, Mehany ABM, El-Agrody AM, Okasha RM. Halawa AH, et al. Among authors: okasha rm. Int J Mol Sci. 2019 Nov 8;20(22):5592. doi: 10.3390/ijms20225592. Int J Mol Sci. 2019. PMID: 31717402 Free PMC article.

9

First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents.

Okasha RM, Alsehli M, Ihmaid S, Althagfan SS, El-Gaby MSA, Ahmed HEA, Afifi TH. Okasha RM, et al. Bioorg Chem. 2019 Nov;92:103262. doi: 10.1016/j.bioorg.2019.103262. Epub 2019 Sep 5. Bioorg Chem. 2019. PMID: 31518757

10

A New Family of Benzo[h]Chromene Based Azo Dye: Synthesis, In-Silico and DFT Studies with In Vitro Antimicrobial and Antiproliferative Assessment.

Abd-El-Aziz AS, Alsaggaf A, Assirey E, Naqvi A, Okasha RM, Afifi TH, Hagar M. Abd-El-Aziz AS, et al. Among authors: okasha rm. Int J Mol Sci. 2021 Mar 10;22(6):2807. doi: 10.3390/ijms22062807. Int J Mol Sci. 2021. PMID: 33802075 Free PMC article.

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