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Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins.
Xu Y, Chandarajoti K, Zhang X, Pagadala V, Dou W, Hoppensteadt DM, Sparkenbaugh EM, Cooley B, Daily S, Key NS, Severynse-Stevens D, Fareed J, Linhardt RJ, Pawlinski R, Liu J. Xu Y, et al. Among authors: pagadala v. Sci Transl Med. 2017 Sep 6;9(406):eaan5954. doi: 10.1126/scitranslmed.aan5954. Sci Transl Med. 2017. PMID: 28878012 Free PMC article.
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors.
Byrne DP, Li Y, Ramakrishnan K, Barsukov IL, Yates EA, Eyers CE, Papy-Garcia D, Chantepie S, Pagadala V, Liu J, Wells C, Drewry DH, Zuercher WJ, Berry NG, Fernig DG, Eyers PA. Byrne DP, et al. Among authors: pagadala v. Biochem J. 2018 Aug 14;475(15):2417-2433. doi: 10.1042/BCJ20180265. Biochem J. 2018. PMID: 29934491 Free PMC article.
Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure.
Arnold K, Xu Y, Sparkenbaugh EM, Li M, Han X, Zhang X, Xia K, Piegore M, Zhang F, Zhang X, Henderson M, Pagadala V, Su G, Tan L, Park PW, Stravitz RT, Key NS, Linhardt RJ, Pawlinski R, Xu D, Liu J. Arnold K, et al. Among authors: pagadala v. Sci Transl Med. 2020 Mar 18;12(535):eaav8075. doi: 10.1126/scitranslmed.aav8075. Sci Transl Med. 2020. PMID: 32188725 Free PMC article.
28 results