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Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation.
Wu C, Rakhshandehroo T, Wettersten HI, Campos A, von Schalscha T, Jain S, Yu Z, Tan J, Mose E, Childers BG, Lowy AM, Weis SM, Cheresh DA. Wu C, et al. Among authors: childers bg. Nat Cell Biol. 2023 Feb;25(2):309-322. doi: 10.1038/s41556-022-01055-y. Epub 2023 Jan 16. Nat Cell Biol. 2023. PMID: 36646789 Free PMC article.
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages.
Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. Babicky ML, et al. Oncogene. 2019 Jul;38(28):5599-5611. doi: 10.1038/s41388-019-0811-9. Epub 2019 Apr 9. Oncogene. 2019. PMID: 30967626 Free PMC article.