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A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healing.
Wang Q, Gallardo-Macias R, Vomhof-DeKrey EE, Gupta R, Golovko SA, Golovko MY, Oncel S, Gurvich VJ, Basson MD. Wang Q, et al. Among authors: gallardo macias r. Curr Res Pharmacol Drug Discov. 2022 Dec 23;4:100147. doi: 10.1016/j.crphar.2022.100147. eCollection 2023. Curr Res Pharmacol Drug Discov. 2022. PMID: 36632414 Free PMC article.
Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design.
Rudraraju RS, Daher SS, Gallardo-Macias R, Wang X, Neiditch MB, Freundlich JS. Rudraraju RS, et al. Among authors: gallardo macias r. Front Cell Infect Microbiol. 2022 Sep 15;12:1008213. doi: 10.3389/fcimb.2022.1008213. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189349 Free PMC article. Review.
Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection.
Jadhav R, Gallardo-Macias R, Kumar G, Daher SS, Kaushik A, Bigelow KM, Nuermberger EL, Lamichhane G, Freundlich JS. Jadhav R, et al. Among authors: gallardo macias r. PLoS One. 2021 May 3;16(5):e0249841. doi: 10.1371/journal.pone.0249841. eCollection 2021. PLoS One. 2021. PMID: 33939697 Free PMC article.
Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing.
Wang Q, Gallardo-Macias R, Rashmi, Golovko MY, Elsayed AAR, More SK, Oncel S, Gurvich VJ, Basson MD. Wang Q, et al. Among authors: gallardo macias r. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364. doi: 10.1021/acsmedchemlett.0c00311. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738062 Free PMC article.
Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent.
Gallardo-Macias R, Kumar P, Jaskowski M, Richmann T, Shrestha R, Russo R, Singleton E, Zimmerman MD, Ho HP, Dartois V, Connell N, Alland D, Freundlich JS. Gallardo-Macias R, et al. Bioorg Med Chem Lett. 2019 Feb 15;29(4):601-606. doi: 10.1016/j.bmcl.2018.12.053. Epub 2018 Dec 24. Bioorg Med Chem Lett. 2019. PMID: 30600207 Free PMC article.
Discovery of MRSA active antibiotics using primary sequence from the human microbiome.
Chu J, Vila-Farres X, Inoyama D, Ternei M, Cohen LJ, Gordon EA, Reddy BV, Charlop-Powers Z, Zebroski HA, Gallardo-Macias R, Jaskowski M, Satish S, Park S, Perlin DS, Freundlich JS, Brady SF. Chu J, et al. Among authors: gallardo macias r. Nat Chem Biol. 2016 Dec;12(12):1004-1006. doi: 10.1038/nchembio.2207. Epub 2016 Oct 17. Nat Chem Biol. 2016. PMID: 27748750 Free PMC article.
15 results