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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist.
Cell Metab. 2023 Feb 7;35(2):274-286.e10. doi: 10.1016/j.cmet.2022.12.011. Epub 2023 Jan 10.
Cell Metab. 2023.
PMID: 36630958
Free article.
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X.
Emmerson PJ, et al. Among authors: gonciarz md.
Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28.
Nat Med. 2017.
PMID: 28846098
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Probing the Binding Mechanism of Acylated Peptides to Human Serum Albumin.
Hu H, Ransdell AS, Qu H, Durbin JD, Valenzuela FA, Hernandez-Buquer S, Gonciarz MD.
Hu H, et al. Among authors: gonciarz md.
ACS Chem Biol. 2023 May 19;18(5):1158-1167. doi: 10.1021/acschembio.3c00018. Epub 2023 May 5.
ACS Chem Biol. 2023.
PMID: 37145869
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The oligomeric state of the active Vps4 AAA ATPase.
Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP.
Monroe N, et al. Among authors: gonciarz md.
J Mol Biol. 2014 Feb 6;426(3):510-25. doi: 10.1016/j.jmb.2013.09.043. Epub 2013 Oct 23.
J Mol Biol. 2014.
PMID: 24161953
Free PMC article.
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Biochemical and structural studies of yeast Vps4 oligomerization.
Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.
Gonciarz MD, et al.
J Mol Biol. 2008 Dec 26;384(4):878-95. doi: 10.1016/j.jmb.2008.09.066. Epub 2008 Oct 4.
J Mol Biol. 2008.
PMID: 18929572
Free PMC article.
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Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p.
Yu Z, Gonciarz MD, Sundquist WI, Hill CP, Jensen GJ.
Yu Z, et al. Among authors: gonciarz md.
J Mol Biol. 2008 Mar 21;377(2):364-77. doi: 10.1016/j.jmb.2008.01.009. Epub 2008 Jan 12.
J Mol Biol. 2008.
PMID: 18280501
Free PMC article.
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