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Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling.
Barber J, Al-Majdoub ZM, Couto N, Howard M, Elmorsi Y, Scotcher D, Alizai N, de Wildt S, Stader F, Sepp A, Rostami-Hodjegan A, Achour B. Barber J, et al. Among authors: sepp a. Eur J Pharm Sci. 2023 Mar 1;182:106375. doi: 10.1016/j.ejps.2023.106375. Epub 2023 Jan 7. Eur J Pharm Sci. 2023. PMID: 36626943 Free article.
In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys.
Aweda TA, Cheng SH, Lenhard SC, Sepp A, Skedzielewski T, Hsu CY, Marshall S, Haag H, Kehler J, Jagdale P, Peter A, Schmid MA, Gehman A, Doan M, Mayer AP, Gorycki P, Fanget M, Colas C, Smith B, Maier CC, Alsaid H. Aweda TA, et al. Among authors: sepp a. Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):667-678. doi: 10.1007/s00259-022-06012-3. Epub 2022 Oct 28. Eur J Nucl Med Mol Imaging. 2023. PMID: 36305907 Free PMC article.
Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells.
Winer BY, Settle AH, Yakimov AM, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh A, Sepp AL, Galiano M, Wong YY, Perry JSA, Geissmann F, Cross J, Zhou T, Kam LC, Pasoli HA, Hohl T, Cyster JG, Weiner OD, Huse M. Winer BY, et al. Among authors: sepp al. bioRxiv [Preprint]. 2023 Sep 13:2023.09.12.556572. doi: 10.1101/2023.09.12.556572. bioRxiv. 2023. PMID: 37745515 Free PMC article. Preprint.
Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation.
Stach L, Dinley EKH, Tournier N, Bingham RP, Gormley DA, Bramhall JL, Taylor A, Clarkson JE, Welbeck KA, Harris CL, Feeney M, Hughes JP, Sepp A, Batuwangala TD, Kitchen SJ, Nichols EM. Stach L, et al. Among authors: sepp a. Antibodies (Basel). 2021 Oct 12;10(4):39. doi: 10.3390/antib10040039. Antibodies (Basel). 2021. PMID: 34698051 Free PMC article.
44 results