Scotcher D - Search Results

1

Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling.

Barber J, Al-Majdoub ZM, Couto N, Howard M, Elmorsi Y, Scotcher D, Alizai N, de Wildt S, Stader F, Sepp A, Rostami-Hodjegan A, Achour B. Barber J, et al. Among authors: scotcher d. Eur J Pharm Sci. 2023 Mar 1;182:106375. doi: 10.1016/j.ejps.2023.106375. Epub 2023 Jan 7. Eur J Pharm Sci. 2023. PMID: 36626943 Free article.

2

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance.

Scotcher D, Jones C, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. Eur J Pharm Sci. 2016 Oct 30;94:59-71. doi: 10.1016/j.ejps.2016.03.018. Epub 2016 Mar 28. Eur J Pharm Sci. 2016. PMID: 27033147 Free PMC article.

3

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data.

Scotcher D, Jones C, Posada M, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. AAPS J. 2016 Sep;18(5):1067-1081. doi: 10.1208/s12248-016-9942-x. Epub 2016 Jun 30. AAPS J. 2016. PMID: 27365096 Review.

4

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation.

Scotcher D, Jones C, Posada M, Galetin A, Rostami-Hodjegan A. Scotcher D, et al. AAPS J. 2016 Sep;18(5):1082-1094. doi: 10.1208/s12248-016-9959-1. Epub 2016 Aug 9. AAPS J. 2016. PMID: 27506526 Review.

5

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.

Scotcher D, Jones CR, Galetin A, Rostami-Hodjegan A. Scotcher D, et al. J Pharmacol Exp Ther. 2017 Mar;360(3):484-495. doi: 10.1124/jpet.116.237438. Epub 2017 Jan 5. J Pharmacol Exp Ther. 2017. PMID: 28057840 Free PMC article.

6

Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance.

Scotcher D, Billington S, Brown J, Jones CR, Brown CDA, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. Drug Metab Dispos. 2017 May;45(5):556-568. doi: 10.1124/dmd.117.075242. Epub 2017 Mar 7. Drug Metab Dispos. 2017. PMID: 28270564 Free PMC article.

7

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance.

Matsuzaki T, Scotcher D, Darwich AS, Galetin A, Rostami-Hodjegan A. Matsuzaki T, et al. Among authors: scotcher d. J Pharmacol Exp Ther. 2019 Feb;368(2):157-168. doi: 10.1124/jpet.118.251413. Epub 2018 Nov 9. J Pharmacol Exp Ther. 2019. PMID: 30413628

8

Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.

van der Made TK, Fedecostante M, Scotcher D, Rostami-Hodjegan A, Sastre Toraño J, Middel I, Koster AS, Gerritsen KG, Jankowski V, Jankowski J, Hoenderop JGJ, Masereeuw R, Galetin A. van der Made TK, et al. Among authors: scotcher d. Mol Pharm. 2019 Nov 4;16(11):4551-4562. doi: 10.1021/acs.molpharmaceut.9b00681. Epub 2019 Sep 27. Mol Pharm. 2019. PMID: 31525064

9

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions.

Scotcher D, Arya V, Yang X, Zhao P, Zhang L, Huang SM, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. CPT Pharmacometrics Syst Pharmacol. 2020 May;9(5):282-293. doi: 10.1002/psp4.12508. Epub 2020 May 14. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32410382 Free PMC article.

10

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations.

Scotcher D, Arya V, Yang X, Zhao P, Zhang L, Huang SM, Rostami-Hodjegan A, Galetin A. Scotcher D, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Jun;9(6):310-321. doi: 10.1002/psp4.12509. Epub 2020 May 22. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32441889 Free PMC article.

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